Circulating levels of 8 cytokines and marine n-3 fatty acids and indices of obesity in Japanese, white, and Japanese American middle-aged men.

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
Akira SekikawaERA JUMP Study group

Abstract

This study examines the differences in circulating levels of cytokines among Japanese in Japan (JJ), Japanese Americans (JA), and whites and their associations with obesity and marine n-3 fatty acids (FA) in a cross-sectional population-based study of 297 men aged 40-49 (100 JJ, 99 whites, and 98 JA). Experimental studies show that cytokines are associated with obesity positively and marine n-3 FA inversely. Serum interleukin-1alpha (IL-1alpha), IL-1 receptor agonist (IL-1ra), IL-4, IL-8, IL-10, inducible protein-10 (IP-10), tumor necrosis factor-alpha (TNF-alpha), monocyte chemoattractant protein-1 (MCP-1), and marine n-3 FA were determined. Body mass index (BMI), waist circumference, and computed tomography-measured visceral and subcutaneous adipose tissues were determined. The JJ had significantly lower levels of IL-1alpha, IL-4, IL-8, MCP-1, and TNF-alpha than whites and JA. Whites and JA had similar levels of IL-1alpha, IL-4, and IL-8 whereas whites had significantly higher levels of MCP-1 and TNF-alpha than JA. The JJ were least obese (BMI (kg/m(2)), mean +/- standard deviation) 23.6 +/- 2.8, 27.9 +/- 4.6, and 27.9 +/- 4.5 for JJ, whites, and JA, respectively. The JJ had marine n-3 FA about 100% higher than whites and JA ...Continue Reading

References

Apr 5, 1996·Science·E C Butcher, L J Picker
May 16, 1998·BMJ : British Medical Journal·T V Perneger
Apr 6, 2001·Diabetes Care·A ShimadaS Narumi
Mar 13, 2002·The Journal of Clinical Endocrinology and Metabolism·Christoph A MeierJean-Michel Dayer
Apr 17, 2002·American Journal of Respiratory and Critical Care Medicine·Jan C GruttersKenneth I Welsh
Oct 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Marek StraczkowskiIda Kinalska
Mar 12, 2003·The Journal of Clinical Endocrinology and Metabolism·Katherine EspositoDario Giugliano
Sep 18, 2003·American Journal of Physiology. Endocrinology and Metabolism·Jens M BruunBjørn Richelsen
Jan 7, 2004·Nature Reviews. Cancer·Glenn Dranoff
Sep 3, 2004·Journal of Human Hypertension·A Sekikawa, T Hayakawa
Sep 18, 2004·Metabolism: Clinical and Experimental·Magdalena Olszanecka-GlinianowiczAleksander Zurakowski
Nov 3, 2004·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T ChristiansenJ M Bruun
Jun 16, 2005·Diabetes Research and Clinical Practice·Hye Soon ParkRina Yu
Oct 20, 2005·The Journal of Clinical Endocrinology and Metabolism·Luigi FerrucciJack M Guralnik
Feb 1, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T KadowakiH Ueshima
Mar 15, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C-S KimR Yu
Jul 18, 2006·The American Journal of Clinical Nutrition·Philip C Calder
Oct 4, 2007·The Journal of Clinical Endocrinology and Metabolism·Christian HerderStephan Martin
Mar 14, 2008·Journal of Human Hypertension·A AntonelliE Ferrannini
Jun 21, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Alma ZerneckeChristian Weber
Jun 27, 2008·American Journal of Epidemiology·Eric WongLewis Kuller
Aug 2, 2008·Journal of the American College of Cardiology·Akira SekikawaUNKNOWN ERA JUMP (Electron-Beam Tomography, Risk Factor Assessment Among Japanese and U.S. Men in the Post-World War II Birth Cohort
Nov 5, 2008·The Journal of Clinical Investigation·Marc Feldmann
Nov 5, 2008·The Journal of Clinical Investigation·Peter J Barnes
Dec 25, 2008·Autoimmunity Reviews·Eun Young LeeYeong Wook Song
Dec 25, 2008·Circulation·Hirotsugu UeshimaTomonori Okamura

❮ Previous
Next ❯

Citations

Sep 11, 2012·Progress in Lipid Research·Aybike BirerdincAncha Baranova
Apr 14, 2015·Trends in Cardiovascular Medicine·William S Harris
Dec 3, 2014·Journal of Atherosclerosis and Thrombosis·Shin-Ya NagasawaUNKNOWN ERA-JUNP Study Group
Nov 14, 2016·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Ivar A EideTrond Jenssen
Jan 10, 2018·Journal of Cachexia, Sarcopenia and Muscle·Erin E TalbertDenis C Guttridge
Dec 5, 2019·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Rong FanWei-Wei Ma
Jul 22, 2021·Cardiovascular Diabetology·Hélène BihanEmmanuel Cosson

❮ Previous
Next ❯

Software Mentioned

Plex Manager
Bio
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.