Circulating levels of adipose tissue-derived inflammatory factors in elderly diabetes patients with carotid atherosclerosis: a retrospective study

Cardiovascular Diabetology
Wei YangLi Wang

Abstract

Inflammation has been recognized as a key feature of both type 2 diabetes mellitus (T2DM) and atherosclerosis. However, the relationships between circulating levels of novel adipose tissue-derived inflammatory factors, including resistin, vaspin, and visfatin, and the severity of atherosclerosis have not been determined. Moreover, the associations between these inflammatory factors and obesity and insulin resistance in elderly patients remain to be clarified. A cross-sectional study of 256 elderly patients with T2DM admitted in our center was performed. Baseline circulating levels of resistin, vaspin and visfatin were measured with enzyme-linked immunosorbent assays. Ultrasonic evaluations of the carotid arteries of the patients were performed to reflect the severity of systemic atherosclerosis. Patients were classified as having mild, moderate, or severe atherosclerosis according to the results of carotid ultrasonic examination. Circulating levels of the inflammatory factors listed above also were correlated with body mass index (BMI) and homeostasis model assessment of insulin resistance (HOMA-IR). With more severe carotid atherosclerosis, circulating levels of resistin (mild: 2.01 ± 0.23; moderate: 2.89 ± 1.01; severe: 3.12 ...Continue Reading

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Citations

Nov 19, 2019·Minerva endocrinologica·Anna BabinskaKrzysztof Sworczak
Jul 9, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Paulina ŻelechowskaElżbieta Kozłowska
Dec 16, 2020·International Journal of Sports Medicine·Maria Elizabeth Pereira PassosRenata Gorjao
May 14, 2021·Stroke; a Journal of Cerebral Circulation·Russell YanofskyStella S Daskalopoulou

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

SPSS

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