Circulating levels of cytokines and their modulation by intravenous immunoglobulin in multifocal motor neuropathy

Journal of the Peripheral Nervous System : JPNS
Fabrizia TerenghiEduardo Nobile-Orazio

Abstract

We found comparable levels of tumor necrosis factor (TNF)-alpha, interferon-gamma, interleukin (IL)-2, IL-4, IL-10, and IL-12 in the sera of 22 patients with multifocal motor neuropathy (MMN), 12 with amyotrophic lateral sclerosis (ALS), 12 multiple sclerosis, seven chronic inflammatory demyelinating polyneuropathy, five myasthenia gravis, and 13 healthy controls (NS). TNF-alpha levels, however, were higher in 15 (68%) MMN patients than in any NS. In all but one MMN patient tested, TNF-alpha levels repeatedly, albeit slightly, increased after each intravenous immunoglobulin infusion in parallel with clinical improvement and decreased 3-4 weeks after therapy, while in both ALS patients tested, they decreased or remained unchanged. The possible pathogenetic relevance of serum TNF-alpha modification in MMN remains to be clarified.

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Citations

Apr 21, 2010·Journal of Clinical Immunology·W-Ludo van der PolLeonard H van den Berg
Aug 19, 2014·Journal of the Neurological Sciences·Takahiro FurukawaRyuji Kaji
Nov 22, 2011·Revue neurologique·M CohenC Lebrun
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Dec 14, 2007·Expert Opinion on Therapeutic Targets·Thiruma V ArumugamMark P Mattson
Jul 2, 2015·Journal of Neuroinflammation·Jared EhrhartSvitlana Garbuzova-Davis
Sep 1, 2017·Molecular Neurobiology·Kevin M BudgeFayez F Safadi
Nov 28, 2007·Muscle & Nerve·Joerg-Patrick Stübgen
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Mar 5, 2015·The Cochrane Database of Systematic Reviews·T UmapathiJean-Marc Léger

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