Circulating levels of insulin-like growth factors 1 and 2 and somatomedin B in alcoholic patients

Psychiatry Research
A ThamL Wetterberg

Abstract

The levels of insulin-like growth factors 1 and 2 (IGF-1 and IGF-2) and somatomedin B in serum and cerebrospinal fluid (CSF) were investigated in alcoholic patients for 4 weeks after alcohol intake stopped. Throughout the observation period, CSF levels of IGF-2 were significantly decreased compared to those of healthy controls, whereas CSF levels of somatomedin B increased significantly 8 days after alcohol withdrawal and remained elevated throughout the observation period. CSF levels of IGF-2 were significantly correlated to measurements of ventricular enlargement on computed tomography. Somatomedin B levels were significantly correlated to clinical variables such as pulse, temperature, and agitation. No increase in the serum levels of somatomedin B were observed, but an increase in serum IGF levels was found in the patient group.

References

Jan 1, 1978·Acta Psychiatrica Scandinavica. Supplementum·M AsbergG Sedvall
Jan 1, 1975·The Journal of Clinical Investigation·R S YalowR Luft
Oct 1, 1986·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A ThamL Wetterberg
Sep 1, 1980·Psychiatry Research·R Hemmingsen, O S Jørgensen
Apr 10, 1980·Nature·T HökfeltM Schultzberg
Jan 1, 1983·Acta Psychiatrica Scandinavica. Supplementum·T Ishii
Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·S BorgG Sedvall
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·V R SaraL Wetterberg
Oct 1, 1980·Alcoholism, Clinical and Experimental Research·J LusinsK Gurley
Jan 1, 1981·Alcoholism, Clinical and Experimental Research·L A Cala, F L Mastaglia
Jan 1, 1982·Neurobiology of Aging·V R SaraL Wetterberg

❮ Previous
Next ❯

Citations

Jan 1, 1997·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·W Zumkeller

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.