Circulating levels of RANTES in human immunodeficiency virus type 1 infection: effect of potent antiretroviral therapy

The Journal of Infectious Diseases
P AukrustS S Frøland

Abstract

RANTES has been found to suppress human immunodeficiency virus type 1 (HIV-1) replication. To further elucidate the role of this chemokine in HIV-1 infection, RANTES levels were analyzed in serum and platelet-free plasma (PFP) in 53 HIV-1-infected patients and 20 controls. RANTES levels were significantly elevated in both serum and PFP in all clinical stages of HIV-1 infection, with the highest levels in CDC groups A and B. In longitudinal testing, the progressors were characterized by a pronounced decline in serum levels over time; the nonprogressors, however, had only a slight reduction or an increase in RANTES levels. During 16 weeks of indinavir therapy, there was an increase in circulating RANTES levels and enhanced release of RANTES from stimulated CD8+ lymphocytes. The decline in RANTES levels along with disease progression is compatible with RANTES having a beneficial role in HIV-1-infected patients. The increase in RANTES levels during protease inhibitor-containing regimens may represent a previously unrecognized immunologic effect of such therapy.

Citations

Jul 29, 1999·Immunology Letters·A KalinkovichZ Bentwich
Apr 28, 2001·Cytokine & Growth Factor Reviews·T S Stantchev, C C Broder
Oct 23, 2002·Clinical and Experimental Immunology·B Brichacek, M Bukrinsky
Oct 3, 1999·AIDS Research and Human Retroviruses·S ThanS Pahwa
May 4, 1999·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·B TartakovskyI Yust
Jan 1, 2000·Sexually Transmitted Infections·G R KaufmannD A Cooper
Oct 27, 2007·American Journal of Respiratory and Critical Care Medicine·Kari OtterdalJan K Damås
Jul 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ping AnCheryl A Winkler
May 12, 2012·Drug Discovery Today. Disease Mechanisms·Kelly A Metcalf Pate, Joseph L Mankowski
May 4, 2004·The Journal of Laboratory and Clinical Medicine·Ping YeDenise E Kirschner
Dec 6, 2000·Journal of Psychopharmacology·S HuP K Peterson
Mar 29, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Priya DuggalDavid Vlahov
Jun 19, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·J K NicholsonJ S McDougal
Mar 16, 2004·Clinical Transplantation·Aina HognestadArne K Andreassen
Mar 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Malavika S GiriLuis J Montaner
Feb 8, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Marina PierdominiciFernando Aiuti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.