PMID: 6107264Aug 1, 1980Paper

Circulating levels of sulphasalazine and its metabolites and their relation to the clinical efficacy of the drug in ulcerative colitis

Gut
A K Azad Khan, S C Truelove

Abstract

One hundred and eighty-five patients with ulcerative colitis have been studied serially while receiving regular maintenance treatment with sulphasalazine (SASP) in a dose of 0.5 g four times daily. The circulating levels of the drug and its principal metabolites during remission do not influence the liability to relapse. When relapse does occur, the circulating level of sulphapyridine falls and remains depressed until remission occurs. This fall during a relapse is most pronounced when the patient suffers from universal colitis and is least marked in cases of distal colitis.

References

Dec 1, 1969·Journal of Medical Genetics·D A Evans
Jun 9, 1956·British Medical Journal·S C TRUELOVE, W C RICHARDS

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Citations

Jan 1, 1990·Pharmacology & Therapeutics·K F IlettR F Minchin
Aug 1, 1994·Pharmacology & Therapeutics·S P Travis, D P Jewell
May 1, 1995·Reproductive Toxicology·D Marmor
Sep 1, 2001·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A QasimC A O'Morain
Dec 1, 1985·Annals of the Rheumatic Diseases·T PullarH A Capell
Feb 1, 1983·Journal of Medical Genetics·A K Azad KhanS C Truelove
Jan 20, 2016·International Journal of Pharmaceutics·Amélia C F VieiraSudaxshina Murdan
Feb 1, 1988·British Journal of Clinical Pharmacology·S BondesenE F Hvidberg
Dec 1, 1983·British Journal of Clinical Pharmacology·O Haagen Nielsen, S Bondesen
Feb 1, 1986·International Journal of Andrology·A Giwercman, N E Skakkebaek
Feb 22, 2012·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Hee Ji LeeJ Paul Fawcett
Jan 1, 1997·Acta Oncologica·M RodriguezB Glimelius
Jan 1, 1989·International Journal of Colorectal Disease·K LauritsenJ Rask-Madsen
May 1, 1983·Pharmacotherapy·D M Sack, M A Peppercorn

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