Circulating levels of TNF receptor II are prognostic for patients with peripheral T-cell non-Hodgkin lymphoma

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Christina HeemannDieter Kube

Abstract

Peripheral T-cell non-Hodgkin lymphomas (T-NHL) represent a small but heterogeneous and clinically aggressive subset of NHLs with a poor outcome. Cytokines or their receptors might be associated with the clinical outcome of these lymphomas. Therefore, we tested whether gene variations and serum levels of soluble TNF receptor (TNFR)I (sTNFRI), sTNFRII, interleukin (IL)-10, or sIL-4R are predictive for treatment response in T-NHLs. Peripheral blood DNA from 117 patients with T-NHL treated in prospective clinical trials was subjected to genotyping analysis. Whenever possible, pretreatment sera were obtained, and circulating levels of sTNFRI, sTNFRII, IL-10, and sIL-4R were determined with a specific capture enzyme-linked immunoassay. Patients characterized by TNFRI-609GG (rs4149570) showed a trend toward better event free survival [EFS; univariate: P = 0.041; multivariate: HR, 1.76; confidence interval (CI), 0.99-3.14 with P = 0.056]. A protective role of IL-10-1087A, -824T, and -597A reported in another study was not confirmed in our cohort. Patients with circulating levels of soluble TNFRII ≥2.16 ng/mL had a 2.07-fold increased relative risk for shorter overall survival (OS; univariate: P = 0.0034; multivariate: HR, 2.07; CI, 0....Continue Reading

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Citations

Apr 1, 2016·British Journal of Cancer·Ana BabicKimmie Ng
Feb 23, 2020·Journal of Leukocyte Biology·Kamar-Sulu N AtretkhanySergei A Nedospasov
Mar 24, 2020·Journal of Leukocyte Biology·Michael YangDenise L Faustman
Aug 10, 2017·Oncology Letters·Fuqian YangNana Zhao
Dec 10, 2020·Science Signaling·Heather TorreyDenise L Faustman
May 1, 2021·Cancers·Ekaterina O GubernatorovaSergei A Nedospasov

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