Circulating lipid peroxidation, plasma and erythrocyte antioxidant status in patients with rheumatoid arthritis

Bangladesh Medical Research Council Bulletin
Palanisamy PasupathiR Ramesh Sankar

Abstract

The aim of the study was to investigate the levels of lipid peroxidation, and both plasma and erythrocyte antioxidant states in patients with rheumatoid arthritis. The population consisted of 60 subjects divided into two groups, 30 subjects had evidence of rheumatoid arthritis and age and sex matched healthy subjects were studied as controls. The level of plasma and erythrocyte thiobarbituric acid reactive substances (TBARS) was markedly increased in both the rheumatoid arthritis patients when compared to control subjects. The activities of plasma and erythrocyte antioxidants were significantly decreased in rheumatoid arthritis. C reactive protein, rheumatoid factor and antistreptolysin-O were significantly higher in rheumatoid arthritis patients than in healthy subjects. In conclusion, on the basis of enhanced lipid peroxidation in rheumatoid arthritis patients with concomitant failure of both the plasma, and erythrocyte antioxidants defense mechanism. These results are consistent with the underlying hypothesis that there is an imbalance between reactive oxygen species production and the antioxidant defense system in inflammatory rheumatoid arthritis disease.

Citations

Oct 16, 2014·Journal of Basic and Clinical Pharmacy·Subramani ParasuramanSokkalingam Arumugam Dhanaraj
Sep 28, 2010·Journal of Cellular Biochemistry·France VaillancourtMohamed Benderdour
Mar 17, 2011·SAHARA J : Journal of Social Aspects of HIV/AIDS Research Alliance·Mzikazi Nduna, Jacky Mendes

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