Circulating liver enzymes and risks of chronic diseases and mortality in the prospective EPIC-Heidelberg case-cohort study

BMJ Open
Verena KatzkeRudolf Kaaks

Abstract

Elevated liver enzyme concentrations in blood are indicative of liver diseases and may provide an early signal for being at risk for other chronic diseases. Our study aimed to assess the relationships of alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT), alanine aminotransferase (ALT), aspartate transaminase (AST) and the De Ritis ratio (AST/ALT) with incidence and mortality of cardiovascular diseases (CVD) and the four most common cancers, that is, breast, prostate, colorectal and lung. We analysed a case-cohort sample of the prospective European Prospective Investigation into Cancer and Nutrition-Heidelberg cohort, including cancer (n=1632), cancer mortality (n=761), CVD (n=1070), CVD mortality (n=381) and a random subcohort (n=2739) with an average follow-up duration of 15.6 years. Concentrations of liver enzymes were measured in prediagnostic blood samples and Prentice-weighted Cox regression models were used to estimate HRs with 95% CIs. High ALP levels were associated with increased risk for lung cancer and all-cause mortality (highest vs lowest quartile, multivariable adjusted HR=2.39 (95% CI 1.30 to 4.39), HR=1.31 (95% CI 1.02 to 1.67)), high AST levels with all-cause mortality (HR=1.45 (95% CI 1.15 to 1.82)),...Continue Reading

References

Dec 2, 1999·Journal of Clinical Epidemiology·W E BarlowS Izumi
Feb 1, 1957·Clinica Chimica Acta; International Journal of Clinical Chemistry·F DE RITISG GIUSTI
Apr 17, 2008·Kidney International·M Schoppet, C M Shanahan
Nov 21, 2012·Journal of Clinical Gastroenterology·Constance E Ruhl, James E Everhart
Feb 23, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Sasiwarang Goya WannametheePeter H Whincup
Feb 27, 2013·Pigment Cell & Melanoma Research·Marcus BosenbergRobert Kelsh
Jun 5, 2013·American Journal of Epidemiology·Setor K KunutsorJohn Walley
Jul 10, 2013·BMC Medical Research Methodology·Xiaonan XueHoward D Strickler
Nov 14, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Edith M KoehlerHarry L A Janssen
Mar 4, 2014·International Journal of Epidemiology·Setor K KunutsorJohn Walley
Jul 22, 2014·International Journal of Cancer. Journal International Du Cancer·Setor K KunutsorGianluca Perseghin
Jun 27, 2015·International Journal of Cancer. Journal International Du Cancer·Yejin MokJonathan M Samet
May 24, 2016·Journal of Hepatology·Giovanni TargherCorrado Barbui
Aug 2, 2016·Journal of Clinical Gastroenterology·Suzanne E MahadyJacob George
Jul 6, 2017·International Journal of Clinical Oncology·Jianda HuangJun Ying
Aug 23, 2017·Scientific Reports·Yang ZhouZhi-Li Liu
Jul 15, 2018·BMC Gastroenterology·Tilman KühnJohanna Nattenmüller

❮ Previous
Next ❯

Citations

Oct 23, 2020·International Journal of Cancer. Journal International Du Cancer·Ming-Ming HeMingyang Song
Nov 15, 2020·Environmental Toxicology and Pharmacology·Kehinde Olusola AwotunsinAdebowale Bernard Saba
Jul 6, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Ville T MännistöFredrik Åberg
Feb 2, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·David PetroffJohannes Wiegand
Oct 10, 2021·Internal and Emergency Medicine·Diego Martínez-UrbistondoUNKNOWN RIETE Investigators

❮ Previous
Next ❯

Methods Mentioned

BETA
blood draw

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.