Circulating lncRNA ITSN1-2 is upregulated, and its high expression correlates with increased disease severity, elevated inflammation, and poor survival in sepsis patients

Journal of Clinical Laboratory Analysis
Qingwei ZengShijiang Yang

Abstract

This study aimed to assess the correlation of long noncoding (lnc) RNA intersectin (ITSN) 1-2 expression with disease risk, severity, inflammation, and survival in sepsis patients. Three hundred and nine intensive care unit (ICU)-treated sepsis patients and 300 healthy controls were consecutively recruited in this study. Blood samples were collected from all sepsis patients within 24 hours after admitted to ICU and from healthy controls at the time of health screening, and the expression of lncRNA ITSN1-2 in plasma was detected by quantitative polymerase chain reaction. Disease severity was assessed by physicians using acute physiology and chronic health evaluation (APACHE) II score on day 1 after ICU admission. Additionally, the plasma inflammatory cytokines (including tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), IL-6, IL-8, IL-10, and IL-17) were measured by enzyme-linked immunosorbent assay (ELISA) kits. lncRNA ITSN1-2 was highly expressed in sepsis patients compared to healthy controls and could differentiate sepsis patients from healthy controls with area under the curve (AUC) 0.777 (95% CI: 0.740-0.813). lncRNA ITSN1-2 expression was positively correlated with APACHE II score, C-reactive protein (CRP), TNF-α, ...Continue Reading

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Citations

Jul 31, 2019·International Journal of Molecular Sciences·Zuzana KubiritovaRoman Gardlik
Oct 13, 2020·Current Opinion in Infectious Diseases·Mildred A Iro, Sudha Priya Soundara Pandi
Jun 1, 2021·Frontiers in Cellular and Infection Microbiology·Wei WangTie-Ning Zhang
Aug 14, 2021·Experimental Cell Research·Furong LuYiming Shao

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