Circulating malondialdehyde-modified low-density lipoprotein levels are associated with the presence of thin-cap fibroatheromas determined by optical coherence tomography in coronary artery disease

European Heart Journal Cardiovascular Imaging
Yoshiki MatsuoTakashi Akasaka

Abstract

The importance of oxidized low-density lipoprotein (oxLDL) has been implicated in the process of plaque rupture. However, few previous studies demonstrated the relationship between plaque morphology and oxLDL. We evaluated the relationship between coronary plaque vulnerability assessed by optical coherence tomography (OCT) and circulating malondialdehyde-modified low-density lipoprotein (MDA-LDL). OCT was used to determine plaque vulnerability in 102 patients with acute coronary syndrome (ACS; n = 53) and stable angina pectoris (SAP; n = 49). Circulating levels of MDA-LDL were measured by using enzyme-linked immunosorbent assay. Thin-cap fibroatheromas (TCFAs; defined as lipid-rich with plaque cap thickness <65 μm) were detected more frequently in ACS than in SAP (83% vs. 16%, P < 0.001). The circulating levels of MDA-LDL were significantly higher in patients with ACS compared with SAP (P = 0.008). The levels of MDA-LDL were significantly higher in SAP patients with TCFA than those with non-TCFA (P < 0.001). Although the levels of MDA-LDL were not significant between ACS patients with TCFA and those with non-TCFA, patients with ruptured TCFA had higher levels of MDA-LDL compared with those with morphologically intact TCFA (P = ...Continue Reading

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Citations

Aug 27, 2013·Analytical Biochemistry·Guangbin ZhangQiang Fu
May 24, 2014·European Heart Journal Cardiovascular Imaging·Thor EdvardsenPatrizio Lancellotti
Jul 30, 2014·Journal of Atherosclerosis and Thrombosis·Takashi KuboTakashi Akasaka
Mar 15, 2016·International Heart Journal·Takeshi Soeki, Masataka Sata
Oct 29, 2015·European Heart Journal Cardiovascular Imaging·Mario IannacconeFiorenzo Gaita
Nov 4, 2017·International Journal of Molecular Sciences·Jose Luis Martin-VenturaAna M Briones
Feb 27, 2014·European Heart Journal Cardiovascular Imaging·Patrizio LancellottiGilbert Habib
Aug 31, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Masashi YokoiNobuyuki Ohte
Jul 7, 2020·Hellenic Journal of Cardiology : HJC = Hellēnikē Kardiologikē Epitheōrēsē·S KogantiR D Rakhit

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