Circulating markers of bone turnover

Journal of Nephrology
Marc G VervloetCKD-MBD working group of ERA-EDTA

Abstract

Renal osteodystrophy is a feature of chronic kidney disease (CKD), with increasing prevalence as CKD progresses. This bone disease is responsible for major morbidity, including fractures, and a deterioration in the quality of life and its sequelae. Circulating biomarkers of renal osteodystrophy typically indicate bone turnover, but not other features of bone, like bone volume, mineralization, quality or strength. Bone turnover can be considered to be primarily a reflection of bone cell activity, in particular that of osteoblasts and osteoclasts. Since current treatments for bone disease usually target cellular activity, biomarkers are considered to be able to contribute to the decision-making for treatment and its follow-up. In CKD, one has to consider the impact of a diminished clearance of biomarkers or their altered metabolism, both potentially limiting its clinical use. Here, several aspects of the most frequently used biomarkers of bone turnover are reviewed, with an emphasis on the specific situation represented by CKD. This review is based on the overview lecture at the symposium held in Amsterdam, September 23, 2016: "The Bone In CKD", organized by the CKD-MBD working group of ERA-EDTA.

References

Dec 1, 1989·The Journal of Clinical Endocrinology and Metabolism·P J KellyJ A Eisman
Nov 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M WangY Pei
Feb 1, 1996·Journal of Endocrinological Investigation·A ContiB Ambrosi
Jul 15, 1998·Alimentary Pharmacology & Therapeutics·G D'HaensP Rutgeerts
Oct 7, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·G CoenF Taggi
Sep 27, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K A JohnsonR Terkeltaub
Nov 13, 2001·Kidney International·Z S XiaoH H Zhou
Sep 26, 2002·World Journal of Surgery·Erik NordenströmAnders Bergenfelz
Oct 31, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Göran AnderssonShi-Jin Zhang
Dec 22, 2006·Kidney International·S DisthabanchongR Rajatanavin
Jul 26, 2008·Archives of Gerontology and Geriatrics·R RicciottiC Bertoni-Freddari
Nov 15, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Susan M Ott
Mar 5, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sanford Baim, Paul D Miller
Aug 29, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Carol MooreYahya Osman-Malik
Apr 22, 2011·The Journal of Clinical Endocrinology and Metabolism·Cassianne Robinson-CohenBryan Kestenbaum
May 21, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Christiane DrechslerUNKNOWN NECOSAD Study Group
May 26, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hartmut H MallucheMarie-Claude Monier-Faugere
Dec 25, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Pierre DelanayeEtienne Cavalier
Jul 23, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pierre DelanayeEtienne Cavalier
Aug 30, 2013·Journal of Translational Medicine·Gillian WheaterJacob M van Laar
Dec 3, 2013·BMC Pharmacology & Toxicology·Young-Hee KimSae-Yong Hong
Dec 24, 2013·Current Osteoporosis Reports·Rebecca Baum, Ellen M Gravallese
Mar 20, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yukio MaruyamaYoshiharu Tsubakihara
May 2, 2014·Journal of the American Geriatrics Society·Karin AmreinAstrid Fahrleitner-Pammer
Nov 19, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y NagataS Okuno
Apr 7, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mathias HaarhausHartmut H Malluche
Apr 30, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·José Luis Fernández-MartínUNKNOWN COSMOS group
Sep 1, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Stuart M SpragueSharon M Moe
Sep 18, 2015·BoneKEy Reports·Elizabeth A ZimmermannRobert O Ritchie
Sep 23, 2016·Kidney International·Pieter EvenepoelPablo Ureña Torres

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Citations

Jan 31, 2018·Clinical Chemistry and Laboratory Medicine : CCLM·Samuel Vasikaran
Apr 9, 2019·Endocrine Connections·Stan UrsemAnnemieke C Heijboer
Nov 7, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Justine Bacchetta
Sep 10, 2019·Journal of Medical Biochemistry·Mouna BouksilaAfef Bahlous
Dec 21, 2019·Journal of Nephrology·Maria FusaroPascale Khairallah
Jul 11, 2019·Critical Reviews in Food Science and Nutrition·Masoumeh AkhlaghiFatemeh Sadeghi
Jun 28, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H ChenR T de Jongh
Dec 12, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Dieter Haffner, Maren Leifheit-Nestler
Jun 4, 2020·International Urology and Nephrology·Zahra YariMina Movahedian
Oct 10, 2020·Journal of Medical Biochemistry·Neda MilinkovićSvetlana Ignjatović
Nov 28, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sevcan A BakkalogluUNKNOWN European Society for Paediatric Nephrology (ESPN) Chronic Kidney Disease Mineral and Bone Disorder (CKD-MBD) and Dialysis wo
Nov 18, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Adrien NizetPer Magnusson
Jan 6, 2021·Calcified Tissue International·Jordi BoverCarlos Gómez-Alonso
May 7, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Yadav NishaSmita Kayal

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Methods Mentioned

BETA
imaging
X-ray
biopsies
biopsy

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