Circulating mesenchymal stem cells in patients with hypertrophic cardiomyopathy

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
Maria E MarketouPanos E Vardas

Abstract

This study examines the mobilization of mesenchymal stem cells (MSCs) in patients with hypertrophic cardiomyopathy (HCM) compared to healthy individuals. The pathogenesis of myocardial hypertrophy in HCM is not fully understood. MSCs are involved in the process of neovascularization, fibrosis, and ventricular wall remodeling. We included 40 patients with HCM and 23 healthy individuals. Using flow cytometry, we measured MSCs in peripheral blood, as a population of CD45-/CD34-/CD90+ cells and also as a population of CD45-/CD34-/CD105+ cells. The resulting MSC counts were expressed as percentages of the total cells. Patients with HCM were found to have a greater percentage of circulating CD45-/CD34-CD34-/CD90+ cells compared to controls (0.0041±0.005% vs. 0.0007±0.001%, respectively, P<.001). No significant difference in circulating CD45-/CD34-/CD105+ cells in the peripheral blood was found between HCM patients and controls (0.016±0.018% vs. 0.012±0.014%, respectively, P=.4). Notably, circulating CD45-/CD34-/CD90+ cells were positively correlated with left ventricular mass index (r=0.54, P<.001). Patients with HCM reveal an increased mobilization of MSCs compared to healthy individuals. Although further research is needed to revea...Continue Reading

References

Sep 1, 1986·Journal of the American College of Cardiology·B J MaronW C Roberts
Jun 22, 2002·Nature·Yuehua JiangCatherine M Verfaillie
Jun 25, 2002·The Annals of Thoracic Surgery·Jay G ShakeBradley J Martin
Jul 18, 2002·The Annals of Thoracic Surgery·Takayuki SaitoRay C J Chiu
Jul 25, 2003·Experimental Cell Research·Satoshi GojoAkihiro Umezawa
Feb 24, 2006·European Journal of Haematology·Nancy Van Overstraeten-SchlögelAndré Gothot
Apr 4, 2006·Nature Medicine·Yoshinori MiyaharaHidezo Mori
Apr 25, 2009·Circulation Research·Daniela CesselliPiero Anversa
Sep 8, 2010·The New England Journal of Medicine·Carolyn Y HoChristine E Seidman
Jan 5, 2011·PloS One·Nikolai A SopkoMarc S Penn

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Citations

Jan 29, 2016·Nature Communications·Bonggi LeeJack A Yanovski
Oct 8, 2017·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·R WiegnerR E Brenner
Jan 26, 2021·Frontiers in Cell and Developmental Biology·Amandine GirousseCoralie Sengenès

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