Circulating methylated DNA

Annals of the New York Academy of Sciences
James G Herman

Abstract

Early detection of cancer would facilitate better management of patients, because survival is greatly affected by stage of presentation. Circulating nucleic acids represent a biomarker that might be used in the early detection of cancer. In addition, such biomarkers could potentially be used to follow the progression of patients with cancer. DNA methylation of the promoter region CpG islands of genes represents one such nucleic acid-based marker, and possesses some advantages over other approaches. These include the stability of DNA as a molecule, the ability to detect such changes using simple polymerase chain reaction-based approaches, and the potential for methylated DNA to be preferentially present in nucleosomes in plasma or serum. These factors are presented and their impact on the detection of methylated DNA circulating in the bloodstream is demonstrated.

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Citations

Feb 1, 2009·Biomarkers in Medicine·Stig Linder, Ayodele Alaiya
Sep 26, 2013·International Journal of Molecular Sciences·Yahya I ElshimaliJaydutt V Vadgama
Dec 9, 2008·Cancer Treatment Reviews·Mohd Fahad Ullah, Mohammad Aatif
Jul 22, 2006·International Journal of Cancer. Journal International Du Cancer·Linda C ChuJames G Herman
Sep 1, 2007·Veterinary and Comparative Oncology·D M W SchaeferL J Rush
Jun 21, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Milena GascoAndrea Decensi
Aug 6, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Brian KeeleyTza-Huei Wang
Jan 19, 2012·The Journal of Molecular Diagnostics : JMD·Benjamin P SongYing-Hsiu Su
Dec 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·José Luis RamirezUNKNOWN Spanish Lung Cancer Group
Oct 30, 2008·BioTechniques·Jian-Bing FanDavid Barker
Sep 13, 2008·Expert Review of Molecular Diagnostics·Shi-Wen JiangSean Dowdy
May 20, 2008·Clinical Chemistry·Ugur DeligezerNejat Dalay
Sep 26, 2007·Expert Review of Molecular Diagnostics·Huidong ShiCharles W Caldwell
Jan 7, 2018·Clinical Chemistry and Laboratory Medicine : CCLM·Giorgia GurioliValentina Casadio
Nov 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shigeki YagyuHajime Hosoi
Oct 27, 2005·Molecular Cancer·Alfonso Dueñas-GonzálezEduardo Cervera

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