Circulating Micro-RNAs as Diagnostic Biomarkers for Endometriosis: Privation and Promise

Journal of Minimally Invasive Gynecology
Warren B NothnickJohn R Lue

Abstract

Endometriosis represents a major medical concern in women of reproductive age. One of the remaining major hurdles for successful treatment of endometriosis is the limitation of the process of timely disease diagnosis. A simple blood test for endometriosis-specific biomarkers would offer a more timely accurate diagnosis for the disease, thus allowing for earlier treatment intervention. Although there have been considerable efforts to identify such biomarkers, no clear choice for such noninvasive diagnostic tools has been identified. Micro-RNAs are small noncoding RNAs that have been evaluated intensively as biomarkers for several diseases, and they may hold promise for a diagnosis of endometriosis. In this review, we highlight the need for noninvasive testing for endometriosis, discuss the potential use of micro-RNAs as diagnostic tools for this disease, and consider potential limitations in the use of these small RNA molecules as diagnostic markers for endometriosis.

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Citations

Feb 2, 2016·Systems Biology in Reproductive Medicine·Vladislav S BaranovMaria I Yarmolinskaya
Jul 26, 2017·Clinical Obstetrics and Gynecology·Frances W Grimstad, Alan Decherney
Jul 25, 2018·International Journal of Molecular Sciences·Alessandro La FerlitaCinzia Di Pietro
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Apr 27, 2018·Human Reproduction Update·Kavita PanirM Louise Hull
Feb 8, 2021·Molecular and Cellular Endocrinology·Fatimah Aljubran, Warren B Nothnick
Feb 19, 2021·Journal of Gynecology Obstetrics and Human Reproduction·Sema MisirYüksel Aliyazicioglu
May 7, 2021·Journal of Gynecology Obstetrics and Human Reproduction·Mohummad Hasan Raza RajaRehana Rehman

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