PMID: 3320097Nov 1, 1987Paper

Circulating micromegakaryocytes in myelodysplasia

Journal of Clinical Pathology
W N ErberD Y Mason

Abstract

The alkaline phosphatase-antialkaline phosphatase (APAAP) immunocytochemical staining technique was used to look for circulating cells of megakaryocyte lineage in peripheral blood smears from 67 cases of myelodysplasia. Small numbers of micromegakaryocytes positive for platelet glycoprotein IIIa were found in 23 cases. These cells superficially resemble small lymphoid cells and are hence difficult or impossible to recognise in conventional Romanowsky stained smears. Circulating micromegakaryocytes were found most commonly in more aggressive types of myelodysplasia (such as refractory anaemia with excess blasts (RAEB) and refractory anaemia with excess blasts in transformation (RAEB-t], and their presence may therefore indicate a poor prognosis. Because of the simplicity of this immunocytochemical labelling technique, it could be of wide use in the initial assessment of patients with myelodysplasia, and possibly for the early detection of acute leukaemic transformation.

References

Sep 1, 1985·British Journal of Haematology·T VallespiJ Triginer
Feb 1, 1984·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J L CordellD Y Mason
Nov 1, 1983·British Journal of Haematology·P A TetterooA E von dem Borne
Jun 1, 1982·British Journal of Haematology·J M BennettC Sultan

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Citations

Jan 1, 1991·Virchows Archiv. A, Pathological Anatomy and Histopathology·J Thiele, R Fischer
Jan 1, 2010·Advances in Virology·Sansanee NoisakranGuey Chuen Perng
Mar 1, 1993·Veterinary Pathology·F Colbatzky, W Hermanns
May 16, 2000·Leukemia & Lymphoma·W K HofmannO G Ottmann
May 20, 2020·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Parshw SinghSoniya Nityanand
May 9, 2021·BMJ Case Reports·Garima JainAnita Chopra

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