Circulating MicroRNA-125b Predicts the Presence and Progression of Uremic Vascular Calcification

Arteriosclerosis, Thrombosis, and Vascular Biology
Chia-Ter ChaoHuei-Wen Chen

Abstract

Vascular calcification (VC) is a major cause of mortality in patients with end-stage renal diseases. Biomarkers to predict the progression of VC early are in urgent demand. We identified circulating, cell-free microRNAs as potential biomarkers using in vitro VC models in which both rat and human aortic vascular smooth muscle cells were treated with high levels of phosphate to mimic uremic hyperphosphatemia. Using an Affymetrix microRNA array, we found that miR-125b and miR-382 expression levels declined significantly as biomineralization progressed, but this decline was only observed for miR-125b in the culture medium. A time-dependent decrease in aortic tissue and serum miR-125b levels was also found in both ex vivo and in vivo renal failure models. We examined the levels of circulating, cell-free miR-125b in sera from patients with end-stage renal diseases (n=88) and found an inverse association between the severity of VC and the circulating miR-125b level, irrespective of age or mineral-related hormones (odds ratio, 0.71; P=0.03). Furthermore, serum miR-125b levels on enrollment can predict VC progression years later (for high versus low, odds ratio, 0.14; P<0.01; for the highest versus lowest tertile and middle versus lowes...Continue Reading

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Citations

Sep 29, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Jacqueline S DronRobert A Hegele
Jul 14, 2019·Journal of Cellular and Molecular Medicine·Chia-Ter ChaoHuei-Wen Chen
May 31, 2019·The Journal of International Medical Research·Chien-Te LeeWei-Hung Kuo
Aug 16, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·José M ValdivielsoAlberto Ortiz
Jan 26, 2020·International Journal of Environmental Research and Public Health·Hsiang-Yuan YehHuei-Wen Chen
Sep 3, 2020·Journal of the American Heart Association·Szu-Ying LeeKuo-Chin Huang
Nov 27, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Ning ShiShi-You Chen
Feb 7, 2020·International Journal of Molecular Sciences·Yi-Chou HouKuo-Cheng Lu
May 8, 2020·International Journal of Molecular Sciences·Duk-Hwa KwonHyun Kook
Jul 29, 2020·Journal of Clinical Medicine·Stefanos RoumeliotisCarmine Zoccali
Sep 11, 2020·International Journal of Molecular Sciences·Linsey J F PetersEmiel P C van der Vorst
Oct 26, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Yao LuQingbo Xu
Sep 11, 2020·Pharmacology & Therapeutics·Juhee RyuYoung-Kook Kim
Jan 23, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Philip DüsingFelix Jansen
Jul 3, 2021·International Journal of Molecular Sciences·Chia-Ter Chao, Shih-Hua Lin

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