Circulating MicroRNA-146a and MicroRNA-21 Predict Left Ventricular Remodeling after ST-Elevation Myocardial Infarction

Cardiology
Xiaoxia LiuXueqi Li

Abstract

MicroRNA (miR)-146a and miR-21 have been reported to participate in inflammatory reactions and fibrosis.Excessive inflammation and cardiac fibrosis may play important roles in the development of left ventricular remodeling(LVR). This study assessed whether miR-146a, miR-21 and other biomarkers could predict LVR after myocardial infarction(MI). Circulating miR-146a, miR-21 and other biomarker levels were measured in 198 patients with acute MI 5 days after primary percutaneous coronary intervention(PCI). All patients were assessed by transthoracic echocardiography on day 5 and 1 year after primary PCI. Concentrations of circulating miR-146a, miR-21, C-reactive protein, creatine kinase MB type and troponin I, as well as estimated glomerular filtration rate (eGFR) and left ventricular ejection fraction (LVEF), were significantly higher in patients with than in those without LVR (p < 0.05). Multivariate logistic regression analysis showed that circulating miR-146a (odds ratio, OR = 2.127, p < 0.0001), miR-21 (OR = 1.119,p < 0.0001), eGFR (OR = 0.939, p = 0.0137) and LVEF (OR =0.802, p = 0.0048) were independent predictors of LVR development. The area under the curve for the combination of miR-146a and miR-21 was significantly higher...Continue Reading

Citations

Apr 7, 2017·Pediatric Cardiology·Ma C Sánchez-GómezA Contreras-Ramos
Nov 24, 2016·Journal of Cellular and Molecular Medicine·Yuan GuoDanyan Xu
Feb 19, 2017·Physiological Genomics·Mark R Paterson, Alison J Kriegel
Jun 8, 2018·Acta Pharmacologica Sinica·Shan-Shan ZhouLu Cai
Apr 27, 2018·Acta Pharmacologica Sinica·Chen Wang, Qing Jing
May 20, 2020·International Journal of Molecular Sciences·Teresa L KrammerMatthias Hackl
May 16, 2020·Antioxidants & Redox Signaling·Mohammed Rabiul HosenFelix Jansen
Jan 3, 2020·International Journal of Molecular Medicine·Kun LiGuodong Liu
Jun 17, 2020·Journal of Thrombosis and Thrombolysis·Patrick Malcolm SiegelPhilipp Diehl
Oct 28, 2019·Frontiers in Genetics·Carolina Soler-BotijaAntoni Bayés-Genís
Jul 25, 2019·Cardiovascular Drugs and Therapy·Vince SiebertYochai Birnbaum
Nov 22, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Liang HeJinqiao Qian
May 28, 2019·Clinical Biochemistry·Torkia Lalem, Yvan Devaux
Jun 4, 2021·Ageing Research Reviews·Fabiola OlivieriMassimiliano Bonafè
Jul 3, 2021·International Journal of Molecular Sciences·Shuhan Bu, Krishna K Singh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis