Circulating microRNA-21 is an early predictor of ROS-mediated damage in subjects with high risk of developing diabetes and in drug-naïve T2D

Cardiovascular Diabetology
Lucia La SalaAntonio Ceriello

Abstract

Impaired glucose tolerance (IGT) is a risk factor for the development of diabetes and related complications that ensue. Early identification of at-risk individuals might be beneficial to reduce or delay the progression of diabetes and its related complications. Recently, microRNAs emerged as potential biomarkers of diseases. The aim of the present study was to evaluate microRNA-21 as a potential biomarker for the risk of developing diabetes in adults with IGT and to investigate its downstream effects as the generation of reactive oxygen species (ROS), the induction of manganese-superoxide dismutase-2 (SOD2), and the circulating levels of 4-HNE (4-hydroxynonenal). To evaluate the prognostic and predictive values of plasmatic microRNA-21 in identifying metabolic derangements, we tested a selected cohort (n = 115) of subjects enrolled in the DIAPASON Study, whom were selected on ADA criteria for 2hPG. Statistical analysis was performed using ANOVA or the Kruskal-Wallis test as appropriate. ROC curves were drawn for diagnostic accuracy of the tests; positive and negative predictive values were performed, and Youden's index was used to seek the cut-off optimum truncation point. ROS, SOD2 and 4-HNE were also evaluated. We observed si...Continue Reading

References

Nov 13, 2004·Nature·Matthew N PoyMarkus Stoffel
Jan 22, 2005·Science·Bradford B Lowell, Gerald I Shulman
Nov 5, 2005·Molecular Nutrition & Food Research·Gabriella LeonarduzziGiuseppe Poli
Feb 7, 2006·Cell Metabolism·Christine EsauBrett P Monia
Mar 8, 2006·Clinical Therapeutics·Lawrence A LeiterUNKNOWN International Prandial Glucose Regulation Study Group
Oct 30, 2010·Circulation Research·Ferdinando Giacco, Michael Brownlee
May 27, 2011·The Journal of Biological Chemistry·Nirmalya DeyGoutam Ghosh Choudhury
Jun 2, 2011·Free Radical Biology & Medicine·Koichi Sugamura, John F Keaney
Feb 22, 2012·Science Translational Medicine·B Nelson ChauJeremy S Duffield
Jun 19, 2013·Free Radical Biology & Medicine·Mitsuo KatoRama Natarajan
Feb 28, 2014·Frontiers in Immunology·Paola de CandiaSergio Abrignani
Nov 28, 2014·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Shao QingQinghuai Liu
Dec 23, 2014·The Journal of Clinical Endocrinology and Metabolism·Marcelina PárrizasAnna Novials
Dec 30, 2014·Diabetes Care·UNKNOWN American Diabetes Association
May 11, 2016·Diabetes, Obesity & Metabolism·F PrattichizzoA Ceriello
Jun 10, 2016·International Journal of Medical Sciences·Hung-Yu ChienWan-Chun Li
Nov 20, 2016·The Lancet. Diabetes & Endocrinology·Lydia E Makaroff
Feb 2, 2017·Clinical Diabetes : a Publication of the American Diabetes Association·UNKNOWN American Diabetes Association
Mar 11, 2017·Diabetologia·Emily K SimsCarmella Evans-Molina
Nov 21, 2017·Journal of Visualized Experiments : JoVE·Mavis MensahMattia Boeri
Dec 5, 2017·PloS One·Paola de CandiaAntonio Ceriello
Jun 1, 2018·International Journal of Endocrinology·Giuseppina CatanzaroElisabetta Ferretti
Dec 13, 2018·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Fernanda-Isadora Corona-MerazRosa-Elena Navarro-Hernández

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Citations

Dec 5, 2019·Cells·Srividya VasuBashoo Naziruddin
Nov 15, 2019·European Journal of Preventive Cardiology·Lucia La SalaAntonio Ceriello
Sep 11, 2020·Cardiovascular Diabetology·Karima Ait-AissaModar Kassan
May 14, 2020·International Journal of Molecular Sciences·Cole LiechtyJunwang Xu
Nov 7, 2019·International Journal of Molecular Sciences·Mirza Muhammad Fahd QadirRicardo Luis Pastori
Apr 21, 2020·Journal of Alzheimer's Disease : JAD·Murali Vijayan, P Hemachandra Reddy
Dec 22, 2019·International Journal of Molecular Sciences·Giuseppina Emanuela GriecoGuido Sebastiani
Sep 24, 2020·International Journal of Molecular Sciences·Adam WłodarskiAgnieszka Śliwińska
Nov 5, 2020·International Journal of Molecular Sciences·Lucia La Sala, Antonio E Pontiroli
Dec 31, 2020·International Journal of Molecular Sciences·Lucia La SalaAntonio E Pontiroli
Feb 13, 2021·Journal of Diabetes·Luis Edgar González-SánchezLeticia Andrea Barajas-Nava
Jul 28, 2020·Molecular and Cellular Endocrinology·Lichan TaoYuetao Wang
May 8, 2021·Frontiers in Medicine·Xiaoyun HeChunlin Ou
Jun 4, 2021·Ageing Research Reviews·Fabiola OlivieriMassimiliano Bonafè
Jan 26, 2022·Physiological Reports·Zakieh YazdanpanahMohammad Yahya Vahidi Mehrjardi

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Methods Mentioned

BETA
PCR
electron paramagnetic resonance

Software Mentioned

Win EPR
ROS

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