Circulating microRNAs are associated with Pulmonary Hypertension and Development of Chronic Lung Disease in Congenital Diaphragmatic Hernia

Scientific Reports
Marisol Herrera-RiveroFlorian Kipfmueller

Abstract

Pulmonary hypertension (PH) contributes to high mortality in congenital diaphragmatic hernia (CDH). A better understanding of the regulatory mechanisms underlying the pathology in CDH might allow the identification of prognostic biomarkers and potential therapeutic targets. We report the results from an expression profiling of circulating microRNAs (miRNAs) in direct post-pulmonary blood flow of 18 CDH newborns. Seven miRNAs differentially expressed in children that either died or developed chronic lung disease (CLD) up to 28 days after birth, compared to those who survived without developing CLD during this period, were identified. Target gene and pathway analyses indicate that these miRNAs functions include regulation of the cell cycle, inflammation and morphogenesis, by targeting molecules responsive to growth factors, cytokines and cellular stressors. Furthermore, we identified hub molecules by constructing a protein-protein interaction network of shared targets, and ranked the relative importance of the identified miRNAs. Our results suggest that dysregulations in miRNAs let-7b-5p, -7c-5p, miR-1307-3p, -185-3p, -8084, -331-3p and -210-3p may be detrimental for the development and function of the lungs and pulmonary vascula...Continue Reading

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Citations

Mar 7, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Florian KipfmuellerStefan Holdenrieder
Aug 12, 2020·Briefings in Bioinformatics·Zulkar NainMohammad Ali Moni
May 16, 2019·Pediatric Research·Richard WagnerRichard Keijzer
Feb 23, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Fiammetta PiersigilliVineet Bhandari
Jan 10, 2021·European Journal of Heart Failure·Ankita GargThomas Thum
Jun 3, 2021·Briefings in Bioinformatics·Zulkar NainSudhangshu Kumar Biswas
Aug 4, 2021·BioMed Research International·De-Jian Chen, Da-Peng Li

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Methods Mentioned

BETA
RNA-seq

Software Mentioned

Affymetrix
Reactome FI app
STATISTICA
miRTargetLink
miRSystem
Cytoscape

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