Circulating microRNAs as biomarkers in hepatocellular carcinoma screening: a validation set from China

Medicine
Li JiangMing-Zhi Zhang

Abstract

Hepatocellular carcinoma (HCC) is a global public health concern. Current diagnostic methods show poor performance in early-stage HCC detection. Accumulating evidences revealed the great potential of microRNAs (miRNAs) as noninvasive biomarkers in HCC detection. In this study, we examined the diagnostic performance of serum miR-10b, miR-106b, and miR-181a for HCC screening in China. Furthermore, a systematic review of previous related studies was conducted to confirm our results. One hundred eight participants including 27 HCC patients, 31 chronic liver disease (CLD) patients, and 50 healthy people were recruited in this study. Blood specimen was drawn from each participant to extract serum miRNAs. Statistical analyses were performed to assess the 3 miRNAs levels in HCC, CLD patients, and normal controls. A meta-analysis was conducted to further assess the diagnostic value of miRNAs in HCC detection based on previous studies. All these miRNAs (miR-10b, miR-181a, miR-106b) could well discriminate HCC patients from normal controls, with area under the receiver-operating characteristic curve (AUC) values of 0.85 (95% confidence interval [CI]: 0.76-0.94), 0.82 (95% CI: 0.72-0.91), and 0.89 (95% CI: 0.81-0.97), respectively. In addi...Continue Reading

References

Feb 3, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M F YuenC L Lai
Oct 25, 2006·Nature Reviews. Cancer·George A Calin, Carlo M Croce
May 25, 2007·Cancer Biomarkers : Section a of Disease Markers·Michael L VolkJorge A Marrero
Jun 29, 2007·Nature Clinical Practice. Oncology·Myron SchwartzManousos Konstadoulakis
Jan 17, 2008·Nature Reviews. Genetics·Witold FilipowiczNahum Sonenberg
Jan 29, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Noah T ZinkinNezam H Afdhal
Jul 17, 2008·Proceedings·Gary L DavisRobert M Goldstein
Feb 27, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Don C RockeyUNKNOWN American Association for the Study of Liver Diseases
May 28, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xiaoying ZhangShuhan Sun
Jan 16, 2010·The Journal of Biological Chemistry·Yanyan TianZhihua Liu
Mar 18, 2010·British Journal of Cancer·M TsujiuraE Otsuji
Apr 21, 2010·Cancer Control : Journal of the Moffitt Cancer Center·Eric K Outwater
May 8, 2010·Journal of Hepatology·Changzheng LiuSongsen Chen
Oct 6, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Nam C YuDavid S K Lu
Nov 12, 2010·Breast Cancer Research : BCR·Li Ma
Dec 21, 2010·Biochemical and Biophysical Research Communications·Ki-Hyuk ShinNo-Hee Park
Feb 1, 2011·Journal of Clinical Gastroenterology·Kevin Z QuMaher Albitar
Jul 14, 2011·Journal of Hepatology·Yoshito TomimaruMasaki Mori
Nov 23, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jian ZhouJia Fan
Dec 14, 2011·International Journal of Oncology·Dian-Lei LiuSheng-Zhang Lin
May 15, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiangyang ZhangYuyuang Li
Jan 12, 2013·Journal of Neuro-oncology·Fadila GuessousRoger Abounader
Jun 28, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Yong-Liang YaoQing-Hui Zhang
Oct 16, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jing ShenRegina M Santella

❮ Previous
Next ❯

Citations

Sep 24, 2015·Oncology Reports·Bijing Mao, Ge Wang
Nov 5, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Feng WangShukui Wang
Nov 16, 2016·Biomolecules·Panagiota PapanagnouMaria Tsironi
Nov 28, 2016·Molecular Aspects of Medicine·Jooho LeeSang-Woon Choi
Aug 3, 2019·Molecular Carcinogenesis·Merricka C LivingstoneJohn D Groopman
Sep 9, 2017·World Journal of Gastroenterology : WJG·Wataru OkajimaEigo Otsuji
Jun 21, 2019·MicroRNA·Ioannis A ZiogasGeorgios Tsoulfas
May 23, 2020·International Journal of Cancer. Journal International Du Cancer·Suchandrima GhoshSoma Banerjee
Sep 18, 2015·World Journal of Gastroenterology : WJG·Yu-Cheng ZhangYa-Li Wang
Oct 29, 2019·Cancer Biomarkers : Section a of Disease Markers·Jian LiNing Li
Aug 1, 2019·World Journal of Clinical Cases·Lavinia Alice Balaceanu
Oct 31, 2019·Journal of Cellular Physiology·Farzad RahmaniSeyed M Hassanian
Dec 25, 2019·BioMed Research International·Yao JiangHualin Tao
Nov 23, 2019·World Journal of Gastroenterology : WJG·Moustafa Nouh ElemeeryCheol-Ho Pan
Jun 9, 2017·Molecular and Cellular Biochemistry·Vikrant RaiDevendra K Agrawal
Nov 22, 2019·Frontiers in Molecular Biosciences·Kuldeep DhamaSunil Kumar Joshi
May 24, 2020·Annals of Hepatology·Hugo A Barrera-SaldañaSilvia A Barrera-Barrera
May 1, 2021·Cancers·José D Debes On Behalf Of The Escalon Consortium
May 6, 2021·Diagnostics·Martina FaraldiGiovanni Lombardi
May 30, 2021·Seminars in Cell & Developmental Biology·Meenakshi GuptaMaryam Sarwat

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging technique
biopsy
Assay

Software Mentioned

GraphPad Prism
Stata
GraphPad

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Related Papers

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Li JiangBin-Hao Zhang
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Yanying WangYong Gao
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Dong XueXiao-Zhou He
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Jian YinYanxiao Nie
© 2021 Meta ULC. All rights reserved