Circulating microRNAs as emerging cardiac biomarkers responsive to acute exercise

International Journal of Cardiology
David de Gonzalo-CalvoEduardo Iglesias-Gutiérrez

Abstract

Circulating microRNAs (c-miRNAs) are mediators of intercellular communication with great potential as cardiac biomarkers. The analysis of c-miRNAs in response to physiological stress, such as exercise, would provide valuable information for clinical practice and a deeper understanding of the molecular response to physical activity. Here, we analysed for the first time the acute exercise response of c-miRNAs reported as biomarkers of cardiac disease in a well-characterized cohort of healthy active adults. Blood samples were collected immediately before and after (0 h, 24 h, 72 h) a 10-km race, a half-marathon (HM) and a marathon (M). Serum RNA from 10-km and M samples was extracted and a panel of 74 miRNAs analysed using RT-qPCR. c-miRNA response was compared with a panel of nine cardiac biomarkers. Functional enrichment analysis was performed. Pre- and post-M echocardiographic analyses were carried out. Serum levels of all cardiac biomarkers were upregulated in a dose-dependent manner in response to exercise, even in the absence of symptoms or signs of cardiac injury. A deregulation in the profiles of 5 and 19 c-miRNAs was observed for 10-km and M, respectively. Each race induced a specific qualitative and quantitative alterati...Continue Reading

Citations

Jul 2, 2020·Scandinavian Journal of Medicine & Science in Sports·Manuel Fernández-SanjurjoAlberto Dávalos
Jan 15, 2019·Epigenomics·Christian BärDavid de Gonzalo-Calvo
Jun 5, 2019·Journal of Clinical Medicine·David de Gonzalo-CalvoVicenta Llorente-Cortés
Apr 8, 2020·Frontiers in Genetics·Qiulian ZhouTianhui Wang
May 30, 2019·Journal of Internal Medicine·David de Gonzalo-CalvoVicenta Llorente-Cortés
Jul 18, 2020·International Journal of Molecular Sciences·Alex Cleber Improta-CariaBruno Solano de Freitas Souza
Apr 26, 2020·Journal of Cardiovascular Translational Research·Nana HeHonghua Ye
Dec 10, 2020·Journal of Pharmaceutical and Biomedical Analysis·Maud SavonnetArnaud Buhot
Nov 5, 2020·The EPMA Journal·Adriana Torres CrignaOlga Golubnitschaja
Jul 2, 2021·International Journal of Cardiology·Dana DlouhaJan Pitha
Jul 25, 2021·International Journal of Environmental Research and Public Health·Ceren EyiletenŁukasz A Małek
Aug 28, 2021·International Journal of Environmental Research and Public Health·Damien VitielloVéronique Billat
Oct 15, 2021·Cardiovascular Research·Maarten VanhaverbekeUNKNOWN EU-CardioRNA COST Action CA17129

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