Circulating MicroRNAs Characterizing Patients with Insufficient Coronary Collateral Artery Function

PloS One
Nazanin HakimzadehJan J Piek

Abstract

Coronary collateral arteries function as natural bypasses in the event of coronary obstruction. The degree of collateral network development significantly impacts the outcome of patients after an acute myocardial infarction (AMI). MicroRNAs (miRNAs, miRs) have arisen as biomarkers to identify heterogeneous patients, as well as new therapeutic targets in cardiovascular disease. We sought to identify miRNAs that are differentially expressed in chronic total occlusion (CTO) patients with well or poorly developed collateral arteries. Forty-one CTO patients undergoing coronary angiography and invasive assessment of their coronary collateralization were dichotomized based on their collateral flow index (CFI). After miRNA profiling was conducted on aortic plasma, four miRNAs were selected for validation by real-time quantitative reverse transcription polymerase chain reaction in patients with low (CFI<0.39) and high (CFI>0.39) collateral artery capacity. We confirmed significantly elevated levels of miR423-5p (p<0.05), miR10b (p<0.05), miR30d (p<0.05) and miR126 (p<0.001) in patients with insufficient collateral network development. We further demonstrated that each of these miRNAs could serve as circulating biomarkers to discriminate...Continue Reading

References

May 14, 2004·European Heart Journal·P ElsmanUNKNOWN Zwolle Myocardial Infarction Study Group
Jul 6, 2004·Journal of the American College of Cardiology·Toshiya KurotobiUNKNOWN OACIS Group
Aug 13, 2008·Developmental Cell·Shusheng WangEric N Olson
Aug 13, 2008·Developmental Cell·Jason E FishDeepak Srivastava
Jan 6, 2009·Journal of Cellular and Molecular Medicine·Coen van SolingenAnton Jan van Zonneveld
Feb 27, 2010·Circulation Research·Anke J TijsenYigal M Pinto
Jul 3, 2010·Circulation Research·Stephan FichtlschererStefanie Dimmeler
Aug 26, 2010·The Journal of Biological Chemistry·Stephan H SchirmerNiels van Royen
Nov 5, 2010·Breast Cancer Research : BCR·Carina RothHeidi Schwarzenbach
Jan 20, 2011·Nature Reviews. Genetics·Eric Huntzinger, Elisa Izaurralde
Aug 13, 2011·European Heart Journal·Anja M van der LaanNiels van Royen
Oct 25, 2011·Biochemical and Biophysical Research Communications·Hong JiangZhe-Yu Chen
Mar 1, 2012·Thrombosis and Haemostasis·M Nazari-JahantighA Schober
Jun 27, 2012·Circulation·Stephen E EpsteinMary Susan Burnett
Jan 23, 2013·EMBO Molecular Medicine·Stefanie Dimmeler, Pierluigi Nicotera
Jan 30, 2013·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·N Hakimzadeh, J J Piek
Feb 11, 2014·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Livia A GoldraichLuis E Rohde
Mar 4, 2014·Journal of the American College of Cardiology·Gianluigi CondorelliElena Cavarretta
May 9, 2014·Cellular and Molecular Life Sciences : CMLS·Kärt VarendiJaan-Olle Andressoo
Jul 12, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·James E FaberMichael Simons
Jul 15, 2015·Diabetologia·Juliette RaffortEmmanuel Van Obberghen

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Citations

Feb 26, 2016·Cardiovascular Research·S M J WeltenA Y Nossent
Jan 25, 2017·Biochemical and Biophysical Research Communications·Shiqiang HouXinming Li
Mar 4, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Ling-Ping ZhuGuo-Gang Zhang
Feb 23, 2017·Scientific Reports·Aristotelis ChatziioannouUNKNOWN EnviroGenomarkers project consortium
Sep 25, 2018·Frontiers in Physiology·Kjell E J HåkanssonA Yaël Nossent

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Methods Mentioned

BETA
PCR

Software Mentioned

NormFinder
LinReg
GraphPad Prism
Roche LC
SPSS Statistics

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