Circulating MicroRNAs in Cancer: Potential and Challenge

Frontiers in Genetics
Mengying CuiXuewen Zhang

Abstract

MicroRNAs (miRNAs) are endogenous non-coding small RNA molecules that can be secreted into the circulation and exist in remarkably stable forms. Like intercellular miRNAs, circulating miRNAs participate in numerous regulations of biological process and expressed aberrantly under abnormal or pathological status. The quality and quantity changes of circulating miRNAs are associated with the initiation and progression of cancer and can be easily detected by basic molecular biology techniques. Consequently, considerable effort has been devoted to identify suitable extracellular miRNAs for noninvasive biomarkers in cancer. However, several challenges need to be overcome before the practical application. In this review, we discuss several issues of circulating miRNAs: biological function and basic transport carriers; extracellular cell communication process; roles as reliable cancer biomarkers and usage in targeted cancer therapy; and challenges for clinical application.

References

Nov 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·George Adrian CalinCarlo M Croce
Feb 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·George Adrian CalinCarlo M Croce
Apr 19, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Soo In KimMeehyein Kim
May 3, 2007·JAMA : the Journal of the American Medical Association·Mark BloomstonCarlo M Croce
Mar 26, 2008·Nature Biotechnology·Nitzan RosenfeldIris Barshack
May 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eun Ji NamSunghoon Kim
Jul 1, 2008·Gynecologic Oncology·Douglas D Taylor, Cicek Gercel-Taylor
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick S MitchellMuneesh Tewari
Sep 24, 2008·Molecular and Cellular Biology·Leonard B MaggiJason D Weber
Mar 19, 2009·Genes & Development·Minh T N LeBing Lim
Mar 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Zhibin HuHongbing Shen
Mar 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·D Michiel PegtelJaap M Middeldorp
Apr 1, 2010·The Journal of Biological Chemistry·Nobuyoshi KosakaTakahiro Ochiya
May 19, 2010·Current Opinion in Lipidology·George H Rothblat, Michael C Phillips
Jul 10, 2010·Nucleic Acids Research·Kai WangDavid J Galas
Jul 28, 2010·Nature Reviews. Genetics·Jacek KrolWitold Filipowicz
Sep 18, 2010·Clinical Chemistry·Jessica A WeberKai Wang
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jason D ArroyoMuneesh Tewari
Apr 14, 2011·Clinical Chemistry·Jennifer S McDonaldAlicia Algeciras-Schimnich
Apr 21, 2011·Nature Communications·María MittelbrunnFrancisco Sánchez-Madrid
Jun 8, 2011·Nature Reviews. Clinical Oncology·Maria Angelica CortezGeorge A Calin
Jun 24, 2011·PloS One·Radha DuttaguptaKeith W Jones
Jul 16, 2011·Cancer Treatment Reviews·J GongM Bebawy
Oct 13, 2011·Nucleic Acids Research·Suresh MathivananRichard J Simpson
Nov 23, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jian ZhouJia Fan
Jan 14, 2012·British Journal of Cancer·R J BryantF C Hamdy
Apr 18, 2012·Expert Opinion on Biological Therapy·Cecilia Lässer

❮ Previous
Next ❯

Citations

Jun 10, 2020·IUBMB Life·Rasoul MirzaeiRasoul Yousefimashouf
Jul 28, 2020·Biomarkers in Medicine·Xuezhi HuFangcheng Zhang
Jan 8, 2020·Cancers·Carla Solé, Charles H Lawrie
Aug 28, 2020·Journal of Personalized Medicine·Veronica ZelliEdoardo Alesse
Sep 19, 2020·International Journal of Molecular Sciences·Ishita GuptaHalema Al Farsi
Oct 9, 2019·British Journal of Biomedical Science·P Waller, A D Blann
Feb 19, 2020·Molecular Diagnosis & Therapy·Vaishali AggarwalHardeep Singh Tuli
Feb 12, 2020·Cancers·Matthew G K BeneschDavid N Brindley
May 1, 2020·Clinical and Translational Gastroenterology·Friederike CordesDominik Bettenworth
May 7, 2020·Frontiers in Cell and Developmental Biology·Sara DonzelliGiovanni Blandino
Jun 24, 2020·Biomolecules·Simone DonatiMaria Luisa Brandi
Jan 26, 2020·Scientific Reports·C MooneyC M Greene
Aug 28, 2020·Technology in Cancer Research & Treatment·Haiqin XieJianrong Chen
Sep 23, 2020·International Journal of Molecular Sciences·Melinda SzilágyiBálint Nagy
Mar 7, 2020·International Journal of Molecular Sciences·Zainab Ali SyedaSu Jung Song
Oct 8, 2020·International Journal of Molecular Sciences·Ozal BeylerliGjumrakch Aliev
Oct 8, 2020·International Journal of Molecular Sciences·Veronika HolubekovaZuzana Dankova
Oct 18, 2020·International Journal of Molecular Sciences·Amro M SolimanSrijit Das
Oct 18, 2020·International Journal of Molecular Sciences·Simone DonatiMaria Luisa Brandi
Nov 17, 2020·Frontiers in Oncology·Pedro Luiz Porfirio XavierHeidge Fukumasu
Dec 9, 2020·Epigenomics·María Muñoz-San MartínLluís Ramió-Torrentà
Dec 15, 2020·Current Opinion in Organ Transplantation·Canan KuscuCem Kuscu
Jan 7, 2021·Cancer Metastasis Reviews·Irfete S Fetahu, Sabine Taschner-Mandl
Jan 7, 2021·Nucleic Acids Research·Paulina Galka-MarciniakPiotr Kozlowski
Sep 22, 2020·Archives of Biochemistry and Biophysics·Zhi Xiong ChongWan Yong Ho
Jan 27, 2021·Journal of Vascular and Interventional Radiology : JVIR·Tomas AndrasinaS Nahum Goldberg
Oct 27, 2020·Expert Review of Molecular Diagnostics·Esmat AbdiZahra Taherian-Esfahani
Jan 17, 2021·Seminars in Cancer Biology·Kurataka Otsuka, Takahiro Ochiya
Feb 5, 2021·Frontiers in Bioengineering and Biotechnology·Tarana Siddika, Ilka U Heinemann
Nov 11, 2020·Cell Proliferation·Luyen Tien VuMinh T N Le
Dec 17, 2020·Cancers·Tomasz M GrzywaPaweł K Włodarski
Nov 13, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Isabel GessnerSanjay Mathur
Dec 18, 2020·Frontiers in Oncology·Tiziana AnneseDomenico Ribatti
Apr 30, 2020·Molecular Therapy. Nucleic Acids·Chiranjib ChakrabortySang-Soo Lee
Mar 9, 2021·Frontiers in Oncology·Xueyang CuiYuan Yuan
Mar 12, 2021·Frontiers in Endocrinology·Sharmilee VetrivelAnna Riester

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft
PCR

Software Mentioned

Bioanalyzer

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.