Circulating MicroRNAs in Elderly Type 2 Diabetic Patients

International Journal of Endocrinology
Giuseppina CatanzaroElisabetta Ferretti

Abstract

The circulating microRNAs (miRNAs) associated with type 2 diabetes (T2D) in elderly patients are still being defined. To identify novel miRNA biomarker candidates for monitoring responses to sitagliptin in such patients, we prospectively studied 40 T2D patients (age > 65) with HbA1c levels of 7.5-9.0% on metformin. After collection of baseline blood samples (t0), the dipeptidyl peptidase-IV (DPP-IV) inhibitor (DPP-IVi) sitagliptin was added to the metformin regimen, and patients were followed for 15 months. Patients with HbA1c < 7.5% or HbA1c reduction > 0.5% after 3 and 15 months of therapy were classified as "responders" (group R, n = 34); all others were classified as "nonresponders" (group NR, n = 6). Circulating miRNA profiling was performed on plasma collected in each group before and after 15 months of therapy (t0 and t15). Intra- and intergroup comparison of miRNA profiles pinpointed three miRNAs that correlated with responses to sitagliptin: miR-378, which is a candidate biomarker of resistance to this DPP-IVi, and miR-126-3p and miR-223, which are associated with positive responses to the drug. The translational implications are as immediate as evident, with the possibility to develop noninvasive diagnostic tools to p...Continue Reading

Associated Clinical Trials

Apr 23, 2021·Andrea M. Isidori, Andrea M. Isidori

References

Jul 9, 2002·Diabetes, Obesity & Metabolism·A Mitrakou
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick S MitchellMuneesh Tewari
Sep 2, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giuseppe GianniniAlberto Gulino
Jan 28, 2010·Diabetes Care·Peter C ButlerRobert Elashoff
Apr 13, 2010·Brain Research·Enrico De SmaeleAlberto Gulino
Oct 4, 2011·Cell·Hao ZhuGeorge Q Daley
Mar 23, 2012·Nature Reviews. Molecular Cell Biology·Veerle Rottiers, Anders M Näär
May 1, 2013·Nature Reviews. Endocrinology·Claudiane Guay, Romano Regazzi
Jun 8, 2013·Frontiers in Genetics·Michaela B KirschnerGlen Reid
Jul 2, 2014·Acta Diabetologica·Zhangping YangHongqiang Zhang
Feb 27, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R BijkerkM E J Reinders
Mar 3, 2015·Metabolism: Clinical and Experimental·Chigusa HiguchiJun Wada
Aug 28, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J A Deiuliis
Nov 12, 2015·Bioscience, Biotechnology, and Biochemistry·Linchao DingLianjin Zhong
Feb 18, 2016·Stem Cells International·Giuseppina CatanzaroElisabetta Ferretti
May 15, 2016·Biochimica Et Biophysica Acta·Claudiane Guay, Romano Regazzi
May 26, 2016·Molecular and Cellular Biochemistry·Satish K RautMadhu Khullar
Mar 8, 2017·International Journal of Molecular Sciences·Yuqing HeKai Wang
Jul 14, 2017·Diabetes & Metabolic Syndrome·Maurílio de Souza CazarimCristina Sanches

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Citations

Jun 11, 2020·World Journal of Clinical Cases·Li-Na YanZi-Ling Li
Oct 10, 2020·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Hayat AljaibejiJalal Taneera
Dec 2, 2020·Biomedicines·Hsiuying Wang
Dec 3, 2020·Biomedicines·Tiziana FilardiGiuseppina Catanzaro
Dec 12, 2020·Journal of Extracellular Vesicles·Nea BisterTarja Malm
Apr 4, 2021·International Journal of Molecular Sciences·Hsiuying Wang
Apr 22, 2021·BioMed Research International·Chunting LuZejian Li

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