Circulating MicroRNAs in Young Patients with Acute Coronary Syndrome

International Journal of Molecular Sciences
Kind-Leng TongPooi-Fong Wong

Abstract

Circulating microRNAs (miRNAs) hold great potential as novel diagnostic markers for acute coronary syndrome (ACS). This study sought to identify plasma miRNAs that are differentially expressed in young ACS patients (mean age of 38.5 ± 4.3 years) and evaluate their diagnostic potentials. Small RNA sequencing (sRNA-seq) was used to profile plasma miRNAs. Discriminatory power of the miRNAs was determined using receiver operating characteristic (ROC) analysis. Thirteen up-regulated and 16 down-regulated miRNAs were identified in young ACS patients. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) validation showed miR-183-5p was significantly up-regulated (8-fold) in ACS patients with non-ST-segment elevated myocardial infarction (NSTEMI) whereas miR-134-5p, miR-15a-5p, and let-7i-5p were significantly down-regulated (5-fold, 7-fold and 3.5-fold, respectively) in patients with ST-segment elevated myocardial infarction (STEMI), compared to the healthy controls. MiR-183-5p had a high discriminatory power to differentiate NSTEMI patients from healthy controls (area under the curve (AUC) of ROC = 0.917). The discriminatory power for STEMI patients was highest with let-7i-5p (AUC = 0.833) followed by miR-134-5p and...Continue Reading

References

Aug 19, 1999·The American Journal of Emergency Medicine·W J BradyF Morris
Oct 27, 2001·Science·M Lagos-QuintanaT Tuschl
Mar 21, 2002·Emergency Medicine Journal : EMJ·T PollehnF Morris
Feb 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ligang WuJoel G Belasco
Aug 2, 2008·Nature Cell Biology·Julie Gavard, J Silvio Gutkind
Nov 8, 2008·Clinical Chemistry·Per VengeBertil Lindahl
Aug 22, 2009·Clinical Chemistry·Xu JiNaoharu Iwai
Nov 10, 2009·Biochemical and Biophysical Research Communications·Jing AiBaofeng Yang
Dec 4, 2009·Mayo Clinic Proceedings·Andrew CassarBernard J Gersh
Mar 12, 2010·Clinical Science·Yunhui ChengChunxiang Zhang
Mar 17, 2010·Biochemical and Biophysical Research Communications·Menno HoekstraErik A L Biessen
Apr 17, 2010·Clinical Chemistry·Taichi AdachiNaoharu Iwai
Jun 11, 2010·European Heart Journal·Yuri D'AlessandraMaurizio C Capogrossi
Jul 3, 2010·Circulation Research·Stephan FichtlschererStefanie Dimmeler
Oct 6, 2010·Circulation. Cardiovascular Genetics·Maarten F CorstenBlanche Schroen
Jan 5, 2011·Nucleic Acids Research·Koray D KayaOzlen Konu
Jun 7, 2011·Circulation. Cardiovascular Genetics·Yasuhide KuwabaraTakeshi Kimura
Jul 21, 2011·Journal of Molecular and Cellular Cardiology·Matthew KellyChristopher Semsarian
Aug 3, 2011·Journal of Molecular and Cellular Cardiology·Christian WideraThomas Thum
Sep 14, 2011·Nucleic Acids Research·Marc R FriedländerNikolaus Rajewsky
Sep 29, 2011·Journal of Translational Medicine·Junjie XiaoYi-Han Chen
Nov 22, 2011·Vascular Health and Risk Management·Asli Tanindi, Mustafa Cemri
Nov 29, 2011·European Journal of Heart Failure·Yaron GorenOffer Amir
Feb 15, 2012·International Journal of Cardiology·Fabiola OlivieriAntonio Domenico Procopio
Apr 19, 2012·Nature Reviews. Genetics·Colin C PritchardMuneesh Tewari
Jun 2, 2012·Clinical Cardiology·Carlos Cantú-BritoUNKNOWN REACH Latin America Collaborative Group
Sep 22, 2012·Current Hypertension Reports·Vanessa P M van EmpelPaula A da Costa Martins
Apr 17, 2013·BMC Bioinformatics·Edward Y ChenAvi Ma'ayan
Jun 21, 2013·Current Microbiology·Sung-Min KangHeon-Jin Lee
Dec 3, 2013·Journal of the American College of Cardiology·Yi-Chu LiaoSuh-Hang Hank Juo
May 17, 2014·Molecular and Cellular Biochemistry·Fucheng HeShuling Dong
May 31, 2014·The International Journal of Biochemistry & Cell Biology·Anna WojcickaKrystian Jazdzewski
Jul 12, 2014·BioMed Research International·Elsa Bronze-da-Rocha
Oct 9, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Jin-Feng TangGang Liu
Dec 18, 2014·Genome Biology·Michael I LoveSimon Anders

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Citations

Apr 28, 2020·BioMed Research International·Lijie Wang, Yuanzhe Jin
Feb 14, 2021·European Heart Journal. Acute Cardiovascular Care·Moritz BienerMatthias Mueller-Hennessen
Feb 28, 2020·Pharmacology & Therapeutics·Concetta SchianoClaudio Napoli

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Methods Mentioned

BETA
sRNA-seq
RNA-seq
blood collection
Assay
PCR

Software Mentioned

Ensembl
mESAdb
TargetScan
geNorm
DESeq2
MedCalc
Enrichr
FastQC
GraphPad
miRDeep2

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