Circulating miR-126 and miR-130a levels correlate with lower disease risk, disease severity, and reduced inflammatory cytokine levels in acute ischemic stroke patients

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Fuqiang Jin, Jie Xing

Abstract

To investigate the correlations of five angiogenesis-related miRNA (miR-126, miR-130a, miR-222, miR-218, and miR-185) expression levels with risk, severity, and inflammatory cytokines levels in acute ischemic stroke (AIS) patients. A total of 148 AIS patients and 148 age- and gender-matched controls were consecutively enrolled. Blood samples were collected from AIS patients and controls, and plasma was separated for miRNAs and cytokine level detection. Plasma levels of miRNAs were evaluated by real-time qPCR method, and inflammatory cytokine levels were detected using an enzyme-linked immunosorbent assay (ELISA). Plasma miR-126 and miR-130a expression levels in AIS patients were lower than those of controls, while the levels of miR-222, miR-218, and miR-185 were elevated in AIS patients compared with controls. After pooling the five miRNA expression levels together, the area under the curve (AUC) for predicting AIS risk was 0.840 (95% CI 0.795-0.885) with a sensitivity of 83.8% and a specificity of 69.6% at the best cut-off point. Plasma miR-126 (r = - 0.402, P < 0.001) and miR-130a (r = - 0.161, P = 0.050) levels were negatively correlated with NIHSS scores, while plasma miR-218 level was positively correlated with NIHSS score...Continue Reading

References

Jul 20, 2006·Blood·Laura PolisenoGiuseppe Rainaldi
Jan 6, 2009·Journal of Cellular and Molecular Medicine·Coen van SolingenAnton Jan van Zonneveld
Apr 9, 2009·Biochemical and Biophysical Research Communications·Yangxin LiYong-Jian Geng
Feb 5, 2013·Annals of Neurology·Marc Fisher, Gregory W Albers
May 9, 2013·Stroke; a Journal of Cerebral Circulation·Ralph L SaccoUNKNOWN Council on Nutrition, Physical Activity and Metabolism
May 24, 2013·Chemical Reviews·Haifeng DongXueji Zhang
Jan 23, 2014·Lancet·Valery L FeiginUNKNOWN Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010) and the GBD Stroke Experts Group
Jan 13, 2016·Journal of Cellular and Molecular Medicine·Yuhong ZhouHongli Shan
Mar 1, 2016·The International Journal of Biochemistry & Cell Biology·Hailiang ZhengXiaodong Chen
Jun 29, 2016·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Alireza MajdiSiamak Sandoghchian Shotorbani
Aug 23, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Ting-Ying Liang, Ji-Yu Lou
Sep 13, 2016·Nature Reviews. Neurology·Charles C Esenwa, Mitchell S Elkind
Sep 18, 2016·Lancet·Graeme J Hankey
Oct 21, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Josef Anrather, Costantino Iadecola
Jan 24, 2017·Molecular Medicine Reports·Fangen KongLukun Yang
Apr 4, 2017·Neurosurgical Focus·Craig KilburgMin S Park
May 24, 2017·Journal of Neuropathology and Experimental Neurology·Seyed Esmaeil KhoshnamMaryam Farzaneh
Jun 5, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Hong-Hui YangJian-Min Yao
Aug 5, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Pierre MaitriasLaurent Metzinger
Sep 7, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Fuqiang Jin, Jie Xing

❮ Previous
Next ❯

Citations

Dec 1, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Аida KondybayevaАnatoliy Ivashchenko
May 18, 2020·Journal of Toxicology and Environmental Health. Part a·Hao ChenHaiyan Tong
Apr 30, 2020·Experimental and Therapeutic Medicine·Sha YangXuemei Qiu
May 29, 2019·Stroke; a Journal of Cerebral Circulation·Takumi SonodaTakahiro Ochiya
Apr 15, 2020·Translational Stroke Research·Huiting ZhangXiaotang Ma
Mar 30, 2021·Frontiers in Pediatrics·Salvatore TagliaferriGiuseppe Pignataro

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.