Circulating mir-21 and mir-146a are associated with increased cytokines and CD36 in Algerian obese male participants

Archives of Physiology and Biochemistry
Hassiba BenbaibecheNaim Akhtar Khan

Abstract

Background: The microRNAs have come up as crucial mediators of energy balance and metabolic control. CD36 is potential biomarker of obesity and metabolic syndrome. This study investigates the concentration of miR-146a and miR-21 and CD 36 in blood samples of obese and healthy young participants. We assessed the association of mir-146a and mir-21 with inflammatory states in Algerian young participants.Methods: Our study included male obese, without co-morbidities (n = 29), and healthy participants (n = 13). miRNA and CD36 expression was measured by real-time RT-PCR, respectively, in serum and blood.Results: miR-146a and miR-21 concentrations were significantly decreased; however, CD36 expression was increased in obese subjects. Interestingly, miR-146a and miR-21 concentrations were negatively correlated to IL-6, TNF-α, and CD36 in obese participants.Conclusion: We demonstrate that the downregulation of miR-146a and miR-21 was associated with upregulation of inflammatory state and increased CD36 expression in obese participants.

References

Oct 24, 2006·Endocrine Reviews·Maria E Trujillo, Philipp E Scherer
Apr 21, 2007·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J HectorP Algenstaedt
Sep 2, 2008·Arthritis Research & Therapy·Kaleb M PauleyEdward Kl Chan
Feb 20, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Rebecca T MarquezAnton P McCaffrey
Jun 2, 2010·Nature Reviews. Drug Discovery·Yu-Hua TsengC Ronald Kahn
Jun 11, 2010·Annual Review of Biochemistry·Marc Robert FabianWitold Filipowicz
Jan 21, 2011·Molecular and Cellular Biochemistry·M BalasubramanyamV Mohan
Mar 25, 2011·Metabolic Syndrome and Related Disorders·David J Kennedy, Sangeeta R Kashyap
May 11, 2011·The Journal of Experimental Medicine·Mark P BoldinDavid Baltimore
Jun 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jing ZhouShu Chien
Aug 13, 2011·The Proceedings of the Nutrition Society·Karen A HarfordHelen M Roche
May 15, 2012·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Jan F C GlatzJoost J F P Luiken
Sep 8, 2012·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·H-Y LingD-F Liao
Mar 8, 2013·Inflammation·Giuseppe DerosaPamela Maffioli
Jul 5, 2013·Frontiers in Genetics·A TurchinovichB Burwinkel
Sep 27, 2014·Journal of Diabetes Research·Hao WuLining Miao
Sep 30, 2015·Diabetes/metabolism Research and Reviews·Mirwais OsmaiThomas Mandrup-Poulsen
Mar 16, 2017·Fertility and Sterility·David R MeldrumJoseph C Gambone
Sep 5, 2017·Frontiers in Endocrinology·Xuan GaoDilys J Freeman
Nov 9, 2017·Archives of Physiology and Biochemistry·Samira GhorbaniReza Meshkani

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Citations

May 6, 2021·International Journal of Molecular Sciences·Gopi BattineniSeyed Khosrow Tayebati

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