Circulating miR-21, miR-378, and miR-940 increase in response to an acute exhaustive exercise in chronic heart failure patients

Oncotarget
T XuJ Xiao

Abstract

Congestive heart failure (CHF) is a major cause of hospitalizations, morbidity, and mortality in Western societies. In addition to optimal medical and device therapy, exercise training is an important adjunct treatment option for CHF patients. MicroRNAs (miRNAs, miRs) participate in a variety of physiological and pathological processes. Dynamic regulation of circulating miRNAs during exercise in healthy persons and athletes has recently been documented, however, the response of circulating miRNAs to exercise in CHF patients is undetermined. Twenty-eight CHF patients underwent a symptom-limited incremental cardiopulmonary exercise test on a bicycle ergometer using a standardized exercise protocol of revised Ramp10 programs at Shanghai Tongji Hospital. Blood samples were collected before and immediately after an acute exercise session. RNA was extracted from the serum and selected miRNAs were determined using quantitative polymerase chain reactions. Moreover, inflammatory and muscle damage markers were determined by enzyme linked immunosorbent assays. We found that serum miR-21, miR-378 and miR-940 levels were significantly up-regulated immediately following an acute exercise while the rest were not changed. In addition, no robus...Continue Reading

References

Nov 10, 2009·Biochemical and Biophysical Research Communications·Jing AiBaofeng Yang
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jason D ArroyoMuneesh Tewari
May 26, 2011·Nucleic Acids Research·Andrey TurchinovichBarbara Burwinkel
Sep 2, 2011·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·T FernandesE M Oliveira
Apr 18, 2012·Expert Opinion on Biological Therapy·Cecilia Lässer
Nov 15, 2012·Nature Reviews. Cardiology·Volker Adams, Gerhard Schuler
Apr 19, 2013·Frontiers in Physiology·Wataru AoiToshikazu Yoshikawa
Jun 19, 2013·Journal of Innate Immunity·Anne Mobergslien, Mouldy Sioud
Aug 15, 2013·Heart Failure Reviews·Paola GargiuloPiergiuseppe Agostoni
Dec 24, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Frank C MoorenThomas Thum
Dec 29, 2013·Molecular Immunology·Susan AchbergerPierre L Triozzi
Jan 18, 2014·Journal of Applied Physiology·Aaron L BaggishStephen Y Chan
Feb 28, 2014·Pflügers Archiv : European journal of physiology·Dirk J DunckerJolanda van der Velden
Mar 14, 2014·JACC. Heart Failure·Philip A AdesMichael W Rich
Mar 14, 2014·JACC. Heart Failure·Christopher O'Connor
Apr 20, 2014·The Journal of Clinical Investigation·Claudia BangThomas Thum
Jun 4, 2014·Journal of Cellular and Molecular Medicine·Dandan LiangYi-Han Chen
Jun 22, 2014·Circulation Research·Francesco S LoffredoRichard T Lee
Aug 26, 2014·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Clarissa P C GomesRinaldo W Pereira
Mar 19, 2015·Oncotarget·Xue-Song LiuZhi-Min Yuan
Apr 22, 2015·Oncotarget·Aamir AhmadFazlul H Sarkar
May 15, 2015·Oncotarget·Nicola AmodioPierfrancesco Tassone

❮ Previous
Next ❯

Citations

Apr 12, 2016·Journal of Cellular and Molecular Medicine·Chongjun ZhongHaitao Huang
Jan 21, 2017·BioMed Research International·Pujiao YuLin Che
Apr 17, 2018·Exercise and Sport Sciences Reviews·Manuel Fernández-SanjurjoEduardo Iglesias-Gutiérrez
Jul 26, 2018·Journal of Cardiovascular Pharmacology and Therapeutics·Mohammed Andaleeb ChowdhuryLijun C Liu
Jul 4, 2018·American Journal of Physiology. Endocrinology and Metabolism·Randall F D'SouzaCameron J Mitchell
Nov 6, 2018·The Kaohsiung Journal of Medical Sciences·Lu WangZhou Liu
Oct 30, 2016·Expert Review of Molecular Diagnostics·Tania B LomboDanilo A Tagle
May 22, 2018·Clinical Science·Clarissa P C GomesUNKNOWN Cardiolinc™ network
Nov 18, 2018·International Journal of Molecular Sciences·Alex Cleber Improta CariaBruno Solano de Freitas Souza
Dec 31, 2016·Journal of Applied Physiology·Ryan M SappJames M Hagberg
Apr 9, 2020·Frontiers in Cell and Developmental Biology·Yuelin ZhangHonghua Ye
Apr 8, 2020·Frontiers in Genetics·Qiulian ZhouTianhui Wang
Apr 4, 2017·Acta Physiologica·J Denham
Aug 18, 2018·Oxidative Medicine and Cellular Longevity·Iryna RusanovaDarío Acuña-Castroviejo
Dec 27, 2019·Journal of Strength and Conditioning Research·Franciele Cascaes da SilvaRudney da Silva
Mar 21, 2021·European Journal of Preventive Cardiology·Isabel WitvrouwenEmeline M Van Craenenbroeck
Jul 2, 2017·Progress in Cardiovascular Diseases·Gustavo J J SilvaUlrik Wisløff
May 1, 2021·International Journal of Environmental Research and Public Health·Cristina BenaventePaulino Padial
Jun 4, 2021·Ageing Research Reviews·Fabiola OlivieriMassimiliano Bonafè
Aug 3, 2021·International Journal of Cardiology·Foivos PapaioannouStavros Dimopoulos
Jul 24, 2021·Frontiers in Physiology·M Brennan Harris, Chia-Hua Kuo

❮ Previous
Next ❯

Methods Mentioned

BETA
RNA-seq
enzyme linked immunosorbent assays
ELISA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

United States Armed Forces Medical Journal
W R SCHILLHAMMER
American Journal of Physiology. Heart and Circulatory Physiology
Frank C MoorenThomas Thum
© 2022 Meta ULC. All rights reserved