Circulating myocardial microRNAs from infarcted hearts are carried in exosomes and mobilise bone marrow progenitor cells

Nature Communications
Min ChengGangjian Qin

Abstract

Myocardial microRNAs (myo-miRs) are released into the circulation after acute myocardial infarction (AMI). How they impact remote organs is however largely unknown. Here we show that circulating myo-miRs are carried in exosomes and mediate functional crosstalk between the ischemic heart and the bone marrow (BM). In mice, we find that AMI is accompanied by an increase in circulating levels of myo-miRs, with miR-1, 208, and 499 predominantly in circulating exosomes and miR-133 in the non-exosomal component. Myo-miRs are imported selectively to peripheral organs and preferentially to the BM. Exosomes mediate the transfer of myo-miRs to BM mononuclear cells (MNCs), where myo-miRs downregulate CXCR4 expression. Injection of exosomes isolated from AMI mice into wild-type mice downregulates CXCR4 expression in BM-MNCs and increases the number of circulating progenitor cells. Thus, we propose that myo-miRs carried in circulating exosomes allow a systemic response to cardiac injury that may be leveraged for cardiac repair.

References

Nov 1, 2005·Nature·Jan KrützfeldtMarkus Stoffel
Oct 6, 2010·Circulation. Cardiovascular Genetics·Maarten F CorstenBlanche Schroen
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jason D ArroyoMuneesh Tewari
Jun 7, 2011·Circulation. Cardiovascular Genetics·Yasuhide KuwabaraTakeshi Kimura
Jul 15, 2011·The Journal of Clinical Endocrinology and Metabolism·Vincenza LeoneAlfredo Fusco
Aug 13, 2011·Circulation Research·Susmita SahooDouglas W Losordo
Jan 19, 2012·Clinical Chemistry·Yvan DevauxDaniel R Wagner
Apr 3, 2012·Biochemical and Biophysical Research Communications·Lu-lu ZhangBo Yu
Apr 28, 2012·Circulation Research·Tilanthi M JayawardenaVictor J Dzau
Aug 28, 2012·Journal of Molecular and Cellular Cardiology·Yunhui ChengChunxiang Zhang
Apr 30, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Alain van MilJoost P Sluijter
Dec 21, 2013·Nature Communications·Carolina Villarroya-BeltriFrancisco Sánchez-Madrid
Jan 18, 2014·Circulation Research·Susmita Sahoo, Douglas W Losordo
Mar 1, 2014·Nature Communications·Fatiha TabetKerry-Anne Rye
Apr 1, 2014·Journal of the American College of Cardiology·Douglas W Losordo, Douglas E Vaughan
Aug 28, 2014·Cell Reports·Mario Leonardo SquadritoMichele De Palma
Sep 23, 2014·Cell Reports·Danijela Koppers-LalicD Michiel Pegtel
Dec 17, 2014·Nature Reviews. Cardiology·Reinier A Boon, Stefanie Dimmeler
Mar 1, 2015·Genomics, Proteomics & Bioinformatics·Jian ZhangShuangli Mi
Apr 18, 2015·Journal of the American College of Cardiology·Jose M VicencioSean M Davidson
Jun 17, 2015·Nature Reviews. Genetics·Stefanie Jonas, Elisa Izaurralde
Mar 4, 2017·Theranostics·Pin LiZhiqiang Gao
May 13, 2017·Circulation Research·Frank A W CoumansRienk Nieuwland
Jul 25, 2017·Cellular and Molecular Life Sciences : CMLS·Nina Pettersen Hessvik, Alicia Llorente

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Citations

Jun 20, 2019·Non-coding RNA·Hua XiaoHailing Jin
Oct 9, 2019·The Journal of Clinical Investigation·Changhao ChenTianxin Lin
Jun 25, 2020·Journal of Cellular and Molecular Medicine·Jianchao ZhangJinying Zhang
Sep 3, 2020·American Journal of Physiology. Cell Physiology·Kyle I MentkowskiJennifer K Lang
Sep 24, 2020·Annual Review of Nutrition·Elizabeth M McNeill, Kendal D Hirschi
Jan 11, 2020·Stem Cell Research & Therapy·Khawaja Husnain Haider, Beatrice Aramini
Jan 31, 2020·Frontiers in Cell and Developmental Biology·Jugajyoti Baruah, Kishore K Wary
Jan 25, 2020·Oxidative Medicine and Cellular Longevity·Md Sayed Ali Sheikh
Jan 2, 2020·International Journal of Molecular Sciences·Marco B MorelliGaetano Santulli
Jul 7, 2019·International Journal of Molecular Sciences·Suet Yen ChongJiong-Wei Wang
Jan 11, 2020·Frontiers in Endocrinology·Yi LiLicheng Zhang
May 16, 2020·International Journal of Endocrinology·Yi WangLing-Qing Yuan
May 30, 2020·International Journal of Molecular Sciences·Teresa MancusoEleonora Cianflone
Nov 26, 2020·Nature Communications·Tobias FehlmannAndreas Keller
Feb 4, 2021·Medicinal Research Reviews·Xiang WangLu Cai
Nov 18, 2020·Diagnostics·Marta ZaràSilvia S Barbieri
Oct 6, 2020·JACC. Basic to Translational Science·Juanjuan Zhao, Liming Pei
Jan 30, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Binh Yen NguyenXin Wang
Apr 4, 2021·Biomolecules·Sarah A WalshThomas A Davis
Mar 29, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Ramiro A Villarreal-LealBruna Corradetti
Oct 17, 2020·Cardiovascular Research·Xuekun WuKai C Wollert
Apr 17, 2021·Proteomics·Bethany ClaridgeDavid W Greening
Sep 23, 2020·Trends in Biotechnology·Karl T WagnerMilica Radisic

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Methods Mentioned

BETA
flow cytometry
flow-cytometry
PCR
Protein Assay
transfection

Software Mentioned

Image Lab TM
NIH ImageJ

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