Circulating Neprilysin in Patients With Heart Failure and Preserved Ejection Fraction.

JACC. Heart Failure
Melissa A LyleNaveen L Pereira

Abstract

In heart failure with reduced ejection fraction (HFrEF), elevated soluble neprilysin (sNEP) levels are associated with an increased risk of cardiovascular death, and its inhibition with sacubitril/valsartan has improved survival. This study sought to determine the relevance of sNEP as a biomarker in heart failure with preserved ejection fraction (HFpEF) and to compare circulating sNEP levels in patients with HFpEF with normal controls. A case-control study was performed in 242 symptomatic patients with HFpEF previously enrolled in the Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Heart Failure with Preserved Ejection Fraction (RELAX) and Nitrates's Effect on Activity Tolerance in Heart Failure With Preserved Ejection (NEAT-HFpEF) clinical trials and 891 asymptomatic subjects without HF or diastolic dysfunction (confirmed by NT-proBNP levels <200 pg/ml and echocardiography) who were enrolled in the Prevalence of Asymptomatic Left Ventricular Dysfunction study. sNEP was measured using a sandwich enzyme-linked immunosorbent assay (ELISA) in all subjects. Overall, sNEP levels were lower in HFpEF compared with controls (3.5 ng/ml; confidence interval [CI]: 2.5 to 4.8 vs. 8.5 ng/ml; CI: 7.2 to 10....Continue Reading

Citations

Oct 24, 2019·The New England Journal of Medicine·Christopher M O'Connor, Christopher deFilippi
Feb 7, 2020·Physiological Reports·Laale F AlawiKhalid M Elased
May 20, 2020·Journal of the American Heart Association·Suriya PrausmüllerMartin Hülsmann
Aug 3, 2020·European Journal of Heart Failure·Muthiah VaduganathanScott D Solomon
Sep 19, 2020·Cardiac Failure Review·Noemi PavoMartin Hülsmann
May 12, 2020·The Korean Journal of Internal Medicine·Hong-Mi Choi, Mi-Seung Shin
Jul 17, 2021·Cardiovascular Research·Alexandra PetrainaHarald H H W Schmidt

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