Circulating neurofilament light in ischemic stroke: temporal profile and outcome prediction

Journal of Neurology
Annie PedersenC Jern

Abstract

Neurofilament light chain (NfL) is a marker of neuroaxonal damage. We aimed to study associations between serum NfL (sNfL) concentrations at different time points after ischemic stroke and outcomes. We prospectively included ischemic stroke cases (n = 595, mean age 59 years, 64% males) and assessed outcomes by both the modified Rankin Scale (mRS) and the NIH stroke scale (NIHSS) at 3 months and by mRS at 2 years. In a subsample, long-term (7-year) outcomes were also assessed by both mRS and NIHSS. We used the ultrasensitive single-molecule array assay to measure sNfL in the acute phase (range 1-14, median 4 days), after 3 months and 7 years in cases and once in controls (n = 595). Acute-phase sNfL increased by the time to blood-draw and highest concentrations were observed at 3 months post-stroke. High sNfL associated to stroke severity and poor outcomes, and both associations were strongest for 3-month sNfL. After adjusting for age, previous stroke, stroke severity, and day of blood draw, 3-month sNfL was significantly associated to both outcomes at all time points (p < 0.01 throughout). For all main etiological subtypes, both acute phase and 3-month sNfL were significantly higher than in controls, but the dynamics of sNfL dif...Continue Reading

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Citations

Sep 9, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Claus Vinter Bodker HviidTina Parkner
Jan 23, 2020·Brain Sciences·Kate L LambertsenHelle H Nielsen
Apr 21, 2020·Journal of Alzheimer's Disease : JAD·Yan SunUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Nov 5, 2020·Annals of Clinical and Translational Neurology·Christian BarroHoward L Weiner
Nov 13, 2020·Science Translational Medicine·Tania F GendronLeonard Petrucelli
Apr 4, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Anna StokowskaMarcela Pekna
Jun 29, 2021·Frontiers in Neurology·Xiongjie FuGao Chen

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Methods Mentioned

BETA
blood-draw
blood draw
dissection
imaging techniques
blood-draws

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