Circulating neutrophils from patients with ulcerative colitis have a normal respiratory burst

Inflammation
J M Haydek, A Keshavarzian

Abstract

The hallmark of ulcerative colitis is a diffuse infiltration of neutrophils from the circulation into the colonic mucosa. The underlying mechanism for neutrophil tissue infiltration is unknown. One possible hypothesis is abnormal circulating neutrophils. This hypothesis has been previously tested with conflicting results. The aim of our study was to re-evaluate circulating neutrophil function in the absence of several possible confounding factors. To this end, we measured the respiratory burst of circulating neutrophils in response to two different stimuli by chemiluminescence in patients with active and inactive ulcerative colitis being off all medications. Our results show no significant difference between ulcerative colitis patients and controls in peak chemiluminescence, area-under-the-curve and time to peak comparisons. However, 27% of patients with active ulcerative colitis had an abnormally elevated chemiluminescence to stimuli. In addition, no correlations were seen between disease activity and peak chemiluminescence. Thus circulating neutrophils in the majority of patients with ulcerative colitis do not appear to be either "primed" or hyperactive. This may suggest the presence of local colonic factors that lead to neut...Continue Reading

References

Jan 1, 1978·Scandinavian Journal of Gastroenterology·U KrauseL Juhlin
Feb 9, 1989·The New England Journal of Medicine·S J Weiss
Jan 1, 1986·International Archives of Allergy and Applied Immunology·A Hermanowicz, Z Nawarska
Nov 1, 1986·Scandinavian Journal of Gastroenterology·H W VerspagetC B Lamers
Feb 1, 1985·Digestive Diseases and Sciences·H Faden, T M Rossi
Jun 1, 1982·Scandinavian Journal of Gastroenterology·J Elmgreen, V Binder
Mar 1, 1983·Digestive Diseases and Sciences·A P KirkJ E Lennard-Jones
Jan 1, 1981·Scandinavian Journal of Gastroenterology·A Hermanowicz, Z Nawarska
Jul 1, 1993·Gastroenterology·R N BaldassanoR P MacDermott

❮ Previous
Next ❯

Citations

Apr 30, 2011·Chemical Reviews·Motonao Nakamura, Takao Shimizu
Sep 23, 2011·Chemical Reviews·Jesper Z Haeggström, Colin D Funk
Sep 16, 2009·Mediators of Inflammation·Claude RatthéDenis Girard
Aug 1, 1997·The Journal of Laboratory and Clinical Medicine·A KeshavarzianF Harford
Jan 9, 1998·The Journal of Laboratory and Clinical Medicine·C E RobinsonA Keshavarzian
Jul 11, 2001·Scandinavian Journal of Gastroenterology·Q LiuK Sugawara

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.