Circulating NSILA-s in man: Preliminary studies of stimuli in vivo and of binding to plasma components

The Journal of Clinical Endocrinology and Metabolism
K MegyesiP Gorden

Abstract

The insulin-like peptide NSILA-s (non-suppressible insulin-like activity soluble in acid ethanol) was measured in plasma using gel filtration in acid and a new radioreceptor assay. Total plasma NSILA-s levels, which are elevated in some patients with extrapancreatic tumors and hypoglycemia, were also found to be elevated in pregnancy. Patients with hypopituitarism had subnormal concentrations of total plasma NSILA-s which rose promptly and reached a peak 1 h after intravenous hGH. In contrast ot this acute stimulus, chronic elevation of hGH resulted in an elevated level of NSILA-s in only 1 of 10 acromegalics. In normal subjects, oral glucose loading resulted in a rise in NSILA-s (mean peak equals 151% of basal) while insulin induced hypoglycemia produced a small and variable fall. Among the other conditions studied, anorexia nervosa was associated with low levels of NSILA-s. Using gel filtration we found that at physiologic pH about 93% of endogenous NSILA-s is reversibly bound to larger molecules. We show that in normal adults the insulin-like bioactivity in plasma due to free NSILA-s in the basal state is equal to that exerted by insulin itself, and that the free NSILA-s in the circulation of patients with extra-pancreatic t...Continue Reading

Citations

Oct 1, 1976·Diabetologia·R M El-AllawyK Johansen
Nov 1, 1979·Molecular and Cellular Endocrinology·R C FranklinA C Herington
Feb 1, 1984·Molecular and Cellular Endocrinology·G L Smith
Nov 22, 1979·The New England Journal of Medicine·D R ClemmonsL E Underwood
Feb 14, 1980·The New England Journal of Medicine·L S Phillips, R Vassilopoulou-Sellin
Dec 10, 1981·The New England Journal of Medicine·P GordenJ Roth
May 13, 1982·The New England Journal of Medicine·E R FroeschU Widmer
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·W H Daughaday, M Kapadia
Dec 1, 1983·Annals of Surgery·M E BurtM F Brennan
Feb 1, 1976·The Journal of Clinical Investigation·C R KahnJ Roth
May 1, 1990·The Journal of Clinical Investigation·E T ShapiroH S Tager
Aug 1, 1981·Clinical Endocrinology·A C HeringtonJ C McBain
Nov 1, 1976·Clinics in Endocrinology and Metabolism·V Marks
Mar 1, 1984·Clinics in Endocrinology and Metabolism·L S Phillips, T G Unterman
Mar 1, 1984·Clinics in Endocrinology and Metabolism·R L Hintz
Dec 20, 2017·Journal of Molecular Endocrinology·L A Bach
Mar 9, 1989·The New England Journal of Medicine·J E FradkinJ Roth
Mar 13, 2009·American Journal of Physiology. Cell Physiology·Paulette M Yamada, Kuk-Wha Lee
Jun 1, 1981·The Journal of Urology·S L AsaM I Steinhardt

Related Concepts

Acromegaly
Anorexia Nervosa
Blood Glucose
Fibrosarcoma
Reactive Hypoglycemia
Sheehan Syndrome
Novolin
Polypeptides
Plasma Protein Binding Capacity
Hormone Receptors, Cell Surface

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