Circulating omega-3 polyunsaturated fatty acids and subclinical brain abnormalities on MRI in older adults: the Cardiovascular Health Study

Journal of the American Heart Association
Jyrki K VirtanenDariush Mozaffarian

Abstract

Consumption of tuna or other broiled or baked fish, but not fried fish, is associated with fewer subclinical brain abnormalities on magnetic resonance imaging (MRI). We investigated the association between plasma phospholipid omega-3 polyunsaturated fatty acids (PUFAs), objective biomarkers of exposure, and subclinical brain abnormalities on MRI. In the community-based Cardiovascular Health Study, 3660 participants aged ≥ 65 underwent brain MRI in 1992-1994, and 2313 were rescanned 5 years later. MRIs were centrally read by neuroradiologists in a standardized, blinded manner. Participants with recognized transient ischemic attacks or stroke were excluded. Phospholipid PUFAs were measured in stored plasma collected in 1992-1993 and related to cross-sectional and longitudinal MRI findings. After multivariable adjustment, the odds ratio for having a prevalent subclinical infarct was 0.60 (95% CI, 0.44 to 0.82; P for trend = 0.001) in the highest versus lowest long-chain omega-3 PUFA quartile. Higher long-chain omega-3 PUFA content was also associated with better white matter grade, but not with sulcal or ventricular grades, markers of brain atrophy, or with incident subclinical infarcts. The phospholipid intermediate-chain omega-3...Continue Reading

References

Feb 1, 1991·Annals of Epidemiology·L P FriedA Newman
May 1, 1995·Stroke; a Journal of Cerebral Circulation·J A SimonW S Browner
Nov 25, 2000·British Medical Bulletin·G A Lammie
Oct 10, 2001·Neurology·C BernickUNKNOWN Cardiovascular Health Study Collaborative Reseach Group
Aug 3, 2002·Stroke; a Journal of Cerebral Circulation·Hiroyasu IsoTakashi Shimamoto
Mar 29, 2003·The American Journal of Clinical Nutrition·Barbara HeudeUNKNOWN EVA Study
Jul 23, 2003·Archives of Neurology·Martha Clare MorrisJulie Schneider
Jan 26, 2005·Archives of Internal Medicine·Dariush MozaffarianDavid S Siscovick
Apr 9, 2005·Journal of the American Geriatrics Society·Caterina RosanoAnne B Newman
Jul 11, 2006·Prostaglandins, Leukotrienes, and Essential Fatty Acids·G C Burdge
Jun 22, 2007·Lancet Neurology·Sarah E VermeerPeter J Koudstaal
Oct 9, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Antonio CherubiniLuigi Ferrucci
Sep 10, 2008·The American Journal of Clinical Nutrition·Cécilia SamieriPascale Barberger-Gateau
May 29, 2009·The American Journal of Clinical Nutrition·Elizabeth E DevoreMonique M B Breteler
May 29, 2009·The American Journal of Clinical Nutrition·Edeltraut KrögerDanielle Laurin
Jun 16, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Greg M ColeSally A Frautschy
Jun 24, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Connye N Kuratko, Norman Salem
Feb 19, 2011·Current Hypertension Reports·Cristina SierraErnesto L Schiffrin
Sep 10, 2011·Stroke; a Journal of Cerebral Circulation·Susanna C Larsson, Nicola Orsini
Jan 27, 2012·The Journal of Nutrition·Dariush Mozaffarian, Jason H Y Wu
Aug 3, 2012·Neurology·Cécilia SamieriPascale Barberger-Gateau

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Citations

Dec 17, 2014·Scientific Reports·Songela ChenXiaoming Hu
Jan 11, 2017·Progress in Lipid Research·Erik MessamoreRobert K McNamara
Dec 17, 2014·Current Opinion in Clinical Nutrition and Metabolic Care·Isabelle DenisSylvie Vancassel
Feb 24, 2016·Nutrients·Michael J WeiserM Hasan Mohajeri
Dec 10, 2015·Nutrition Research Reviews·Jim M MontiNeal J Cohen
Jun 25, 2015·The British Journal of Nutrition·Reija MännikköRainer Rauramaa
Jul 11, 2020·Nutrition and Health·Masoumeh AskariAfsane Bahrami
May 15, 2020·Physical Activity and Nutrition·Jang Soo Yook, Minchul Lee
Jul 2, 2019·Therapeutic Advances in Psychopharmacology·Arne Reimers, Hanna Ljung
Mar 5, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yifeng Ling, Hugues Chabriat
Oct 23, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Aline ThomasCécilia Samieri
May 23, 2017·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Robert K McNamaraRobert Krikorian
Apr 10, 2021·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Oscar H Del BruttoRobertino M Mera
Jun 12, 2021·Annals of the New York Academy of Sciences·Zahra JafariMajid H Mohajerani
Jul 27, 2021·Annals of the New York Academy of Sciences·Zahra JafariMajid H Mohajerani
Sep 25, 2018·Lancet Neurology·Nikolaos ScarmeasMary Yannakoulia
Nov 5, 2021·Neurology·Aline ThomasCecilia Samieri

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