Circulating PCSK9 and Risk of Myocardial Infarction: The HUNT Study in Norway

JACC. Basic to Translational Science
Lars E LaugsandThor Ueland

Abstract

The usefulness of circulating proprotein convertase subtilisin-kexin type 9 (PCSK9) as a risk marker of coronary heart disease in the general population remains unclear. In a nested case-control study in Norway, 1,488 incident myocardial infarctions were registered during 11.3 years of follow-up and compared with 3,819 controls. Compared with participants in the lowest quartile of PCSK9, myocardial infarction risk was 47% higher in the highest quartile after adjustment for age and sex. After additional adjustment for low-density lipoprotein cholesterol, the association was strongly attenuated. Thus, circulating PCSK9 does not contribute useful information in the assessment of myocardial infarction risk in the general population beyond the information provided by lipid measurements.

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Citations

Apr 13, 2017·Internal Medicine Journal·Daniel J SchererStephen J Nicholls
Jan 31, 2019·European Journal of Preventive Cardiology·Jürgen H ProchaskaPhilipp S Wild
May 12, 2018·Circulation Research·Michael D ShapiroSergio Fazio
Dec 12, 2020·Archives of Biochemistry and Biophysics·Yanan GuoXi-Long Zheng

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