Circulating perivascular dilatory neuropeptides in hypertension.

Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension
L EdvinssonT Thulin

Abstract

Little is known about perivascular neuropeptides in hypertension in man. In this study we investigated the circulating levels of calcitonin gene-related peptide (CGRP)-, substance P- and vasoactive intestinal peptide-like immunoreactivity in 30 patients with severe hypertension before and after treatment for high blood pressure. Circulating levels of CGRP- and substance P-like immunoreactivity in the hypertensives were significantly different from the corresponding levels in 31 age- and sex-matched normotensive subjects. After normalization of blood pressure the mean levels of CGRP- and substance P-like immunoreactivity did not differ between the two groups. The levels of vasoactive intestinal peptide-like immunoreactivity remained unchanged. These observations suggest that vascular afferent nerves play a part in the maintenance of hypertension.

Citations

Jun 1, 1994·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·P D DrummondP J Goadsby
Jan 29, 2011·Neuropeptides·Sarah-Jane Smillie, Susan D Brain

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