Abstract
Progranulin (PGRN), a novel peptide that has recently emerged as an important regulatory adipokine, is relevant to energy homeostasis and obesity in animals and adult humans. Little is known about its roles in children. The aim of the current study was to determine the potential role of PGRN and explore its relationship to various obesity-related markers in obese children. This was a cross-sectional study composed of 77 children (43 obese and 34 healthy, age 8.68 ± 0.28 and 8.46 ± 0.45 years, resp.). The PGRN levels were significantly higher in obese children (102.44 ± 4.18 ng/mL) comparing to controls (69.32 ± 5.49 ng/mL) (P < 0.05). Moreover, the PGRN levels were positively correlated with triglyceride (TG), total cholesterol (TC), IL-6, systolic blood pressure (SBP), and diastolic blood pressure (DBP) in obese children after adjusted for BMI and age. However, there was no correlation of serum PGRN levels with OGTT-derived dynamic parameters, HOMA-IR, or HOMA-β in obese children. The results suggest that serum PGRN levels are significantly higher in obese children in China and correlate significantly with obesity-related markers. Increased PGRN levels may be involved in the pathological mechanism of childhood obesity.
References
Feb 1, 1990·Biology of Reproduction·O O Anakwe, G L Gerton
Jun 17, 2000·Diabetes Care·E BonoraM Muggeo
Jul 31, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Rachael DanielAndrew Bateman
Aug 21, 2003·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Zhiheng He, Andrew Bateman
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Svetlana Ten, Noel Maclaren
Nov 25, 2004·Diabetes·Gordon C Weir, Susan Bonner-Weir
May 9, 2006·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·G ValerioP Rubba
Apr 16, 2008·The Journal of Pediatrics·Fida BachaSilva A Arslanian
Aug 21, 2008·The Journal of Clinical Endocrinology and Metabolism·I M LibmanS Arslanian
Dec 6, 2008·Diabetes·Byung-Soo YounMatthias Blüher
Dec 23, 2009·The Journal of Experimental Medicine·Fangfang YinAihao Ding
Jun 24, 2010·American Journal of Physiology. Endocrinology and Metabolism·Nora KlötingMatthias Blüher
Nov 19, 2010·PloS One·Anke TönjesMatthias Blüher
Jan 10, 2012·Cell Metabolism·Toshiya MatsubaraSusumu Seino
Oct 4, 2012·Diabetes Care·Judit RichterMathias Fasshauer
Nov 13, 2012·Arthritis Research & Therapy·Atsushi TanakaKoichi Akashi
Mar 12, 2013·Mediators of Inflammation·Hua QuZhenping Hu
Dec 21, 2013·Journal of cardiology·Kazuto NakamuraKenneth Walsh
Jun 28, 2014·Endocrinology·Huixia LiHongzhi Sun
Jun 22, 2015·Prague Medical Report·Kvido Smitka, Dana Marešová
Jun 25, 2015·Disease Markers·Lin XuHongzhi Sun
Dec 24, 2015·Diabetology & Metabolic Syndrome·Bruna Bellincanta Nicoletto, Luis Henrique Canani
Feb 18, 2016·Scientific Reports·Feng LiuYi Lu
Aug 10, 2016·Annals of the New York Academy of Sciences·Jianlu WeiChuanju Liu
Jun 27, 2017·Drug Discovery Today·Vanessa AbellaOreste Gualillo
Sep 16, 2017·Frontiers in Immunology·Ioana MozosAtanas G Atanasov
Oct 11, 2017·Frontiers in Pediatrics·Tammy M Brady
Oct 21, 2017·Brain : a Journal of Neurology·Babykumari P ChitramuthuAndrew Bateman
Nov 25, 2017·Nature Reviews. Endocrinology·Thomas Reinehr
Nov 28, 2017·Journal of Pediatric Endocrinology & Metabolism : JPEM·Eman M AlissaZuhair M Marzouki