Circulating pigment epithelium-derived factor levels are associated with insulin resistance and decrease after weight loss

The Journal of Clinical Endocrinology and Metabolism
M SabaterJ M Fernández-Real

Abstract

We aimed to study circulating pigment epithelium-derived factor (PEDF) in vivo in association with insulin resistance and in vitro in human adipocytes. Circulating PEDF (ELISA) and metabolic profile were assessed in 125 Caucasian men. PEDF levels were also assessed in an independent cohort of subjects (n = 33) to study the effects of changing insulin action. PEDF gene expression and secretion were measured during differentiation of human preadipocytes. In all subjects, PEDF was positively associated with body mass index (r = 0.326; P < 0.0001), waist-to-hip ratio (r = 0.380; P < 0.0001), HbA(1c), and fasting triglycerides and negatively with insulin sensitivity (r = -0.320; P < 0.0001). PEDF levels were significantly increased in subjects with altered glucose tolerance and type 2 diabetes. Of the inflammatory markers measured, PEDF levels were positively associated with serum soluble TNF-α receptor 1 and IL-10 in obese subjects. Interestingly, weight loss led to significantly decreased PEDF concentration from 34.8 ± 19.3 to 22.5 ± 14.2 μg/ml (P < 0.0001). Multiple linear regression analyses revealed that insulin sensitivity contributed independently to explain 14% of the variance in PEDF levels after controlling for the effects...Continue Reading

References

Sep 1, 1991·Experimental Eye Research·J Tombran-TinkL V Johnson
Feb 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·F R SteeleJ Tombran-Tink
Mar 8, 2002·American Journal of Physiology. Endocrinology and Metabolism·José-Manuel Fernandez-RealWifredo Ricart
Jul 4, 2002·Molecular & Cellular Proteomics : MCP·Irina KratchmarovaAkhilesh Pandey
Jul 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kojiro MatsumotoKatsumi Eguchi
Mar 9, 2006·The Journal of Clinical Endocrinology and Metabolism·Sho-Ichi YamagishiTsutomu Imaizumi
Sep 26, 2006·Nature Reviews. Immunology·Herbert Tilg, Alexander R Moschen
Oct 5, 2006·Molecular & Cellular Proteomics : MCP·Sanjin ZvonicJeffrey M Gimble
Dec 15, 2006·Nature·Gökhan S Hotamisligil
May 15, 2007·Gastroenterology·Steven E ShoelsonAfia Naaz
Aug 22, 2008·Diabetes Research and Clinical Practice·Alicia JenkinsJian-Xing Ma
Jul 9, 2009·Cell Metabolism·Seamus CroweMatthew J Watt

❮ Previous
Next ❯

Citations

Nov 29, 2011·Archives of Dermatological Research·Hideki NakajimaShigetoshi Sano
Jun 2, 2011·Chemical Reviews·Rosalind A Coleman, Douglas G Mashek
Jan 16, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J M Moreno-NavarreteJ M Fernández-Real
Oct 1, 2011·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Andreas OberbachHolger Till
Dec 28, 2012·American Journal of Physiology. Endocrinology and Metabolism·Jianping Ye, Owen P McGuinness
Aug 30, 2012·The Journal of Clinical Endocrinology and Metabolism·Kyle L SunderlandKevin R Short
Jun 21, 2012·Molecular Medicine·Sangeeta S ChavanKevin J Tracey
May 30, 2014·Nutrition Research Reviews·Gema FrühbeckAmaia Rodríguez
May 7, 2013·Expert Opinion on Drug Discovery·Susan E CrawordOlga V Volpert
Nov 26, 2015·Archives of Physiology and Biochemistry·Lisa ScheringHenrike Sell
Jun 16, 2012·Journal of Biomedicine & Biotechnology·Matthew L BroadheadCrispin R Dass
Dec 25, 2015·Molecular and Cellular Endocrinology·Revathy CarnagarinCrispin R Dass
Jan 10, 2016·Journal of Experimental & Clinical Cancer Research : CR·Louiza Belkacemi, Shaun Xiaoliu Zhang
Feb 15, 2011·European Journal of Clinical Investigation·Alexander TschonerChristoph F Ebenbichler
Jan 18, 2012·Clinical Endocrinology·Safak AkınAlper Gürlek
Feb 1, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·J GalhardoJ P H Shield
Apr 23, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·S PekC F Sum
Mar 8, 2016·Expert Review of Clinical Immunology·Barbara TolussoElisa Gremese
Dec 3, 2014·Molecular and Cellular Endocrinology·Revathy CarnagarinCrispin R Dass
Feb 25, 2014·Journal of Diabetes and Its Complications·Alicia J JenkinsUNKNOWN VADT investigators
Nov 27, 2014·Frontiers in Immunology·Elisa GremeseGianfranco Ferraccioli
Jul 19, 2013·Mediators of Inflammation·Silja Raschke, Jürgen Eckel
Jun 28, 2016·The International Journal of Biochemistry & Cell Biology·Revathy CarnagarinCrispin R Dass
Dec 22, 2017·Indian Journal of Dermatology·Saumya PandaNilendu Sarma
Sep 20, 2018·Biomarkers in Medicine·Federico Carbone, Fabrizio Montecucco
Mar 21, 2019·Current Pharmaceutical Design·Sho-Ichi YamagishiMinoru Yagi
May 18, 2019·Endocrine Reviews·Matthew J WattMagdalene K Montgomery
Jul 28, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Arijeet K GattuChuhan Chung
Oct 4, 2019·Nature Metabolism·Cintia FolgueiraRuben Nogueiras
Sep 4, 2015·American Journal of Physiology. Endocrinology and Metabolism·Amaia RodriguezGema Frühbeck
Aug 31, 2018·Nature Reviews. Gastroenterology & Hepatology·Cornelia M UlrichStephen D Hursting

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.