Abstract
Platelet-derived microparticles (PDMPs) measurement adds prognostic implication for ST-elevation acute myocardial infarction (STEMI). The long-term implication of PDMPs in STEMI needs to be corroborated. The research design was a cohort study. Subjects were STEMI patients and were enrolled consecutively. The PDMPs were defined as microparticles bearing CD41(+) and CD62P(+) markers detected with flow cytometry. The PDMPs were measured on hospital admission and 30 days after discharge. The outcomes were major adverse cardiac events (MACE), i.e., a composite of cardiac death, heart failure, cardiogenic shock, reinfarction, and resuscitated ventricular arrhythmia, occurring from hospitalization until 1 year after discharge. We enrolled 101 subjects with STEMI. During hospitalization, 17 subjects (16.8%) developed MACE. The PDMPs were not different between subjects with MACE and those without (median (IQR): 3305.0/μL (2370.0-14690.5/μL) vs. 4452.0/μL (2024.3-14396.8/μL), p=0.874). Forty-five subjects had increased PDMPs in 30 days after discharge as compared with on-admission measurement. Subjects with increased PDMPs had significantly higher 30-day MACE as compared to subjects with decreased PDMPs 17 (37.8%) vs. 6 (16.7%, p=0.036)....Continue Reading
References
Aug 18, 2004·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Judy A CraftNeville A Marsh
Aug 20, 2011·Circulation Research·Pierre-Emmanuel RautouChantal M Boulanger
Feb 7, 2012·Archives of Medical Research·Ewa StępieńIwona Wybrańska
Mar 29, 2012·European Heart Journal·Italo PortoFilippo Crea
Jun 23, 2012·Pharmacological Reviews·Edwin van der PolRienk Nieuwland
Aug 28, 2012·Circulation·Kristian ThygesenShanti Mendis
Sep 15, 2012·JACC. Cardiovascular Imaging·William ChanAndrew J Taylor
Feb 21, 2013·Atherosclerosis·Pil-Ki MinHyuck Moon Kwon
Mar 29, 2013·Circulation Research·Anne-Clémence VionChantal M Boulanger
Apr 29, 2015·PloS One·Patrick HornPetra Kleinbongard
Aug 5, 2015·Journal of Thrombosis and Haemostasis : JTH·R SuadesL Badimon
Sep 30, 2015·Seminars in Thrombosis and Hemostasis·Mikael ÅbergAgneta Siegbahn
Mar 8, 2016·Journal of Comparative Effectiveness Research·Eleanor R JoyChris P Gale
Jun 10, 2016·Archives of Medical Science : AMS·Anggoro Budi HartopoBudi Yuli Setianto
Aug 25, 2016·Cardiology·Georgios GiannopoulosSpyridon Deftereos
Dec 5, 2016·International Journal of Cardiology·Gemma Chiva-BlanchIngebjørg Seljeflot
Feb 17, 2017·PloS One·Gemma Chiva-BlanchIngebjørg Seljeflot
Apr 21, 2017·Thrombosis and Haemostasis·Christina ChristerssonAgneta Siegbahn
Jul 25, 2017·Journal of the American Heart Association·Chika KawashimaKouichi Tamura
Sep 10, 2017·European Heart Journal·Borja IbanezUNKNOWN ESC Scientific Document Group
Mar 17, 2018·International Journal of Cardiology·A SionisL Badimon
Jul 27, 2018·Cardiology Research and Practice·Anggoro Budi HartopoIra Puspitawati
Nov 30, 2019·Frontiers in Pharmacology·Francesco TausPietro Minuz