Circulating platelets as liquid biopsy sources for cancer detection.

Molecular Oncology
Mafalda Antunes-FerreiraThomas Wurdinger

Abstract

Nucleic acids and proteins are shed into the bloodstream by tumor cells and can be exploited as biomarkers for the detection of cancer. In addition, cancer detection biomarkers can also be nontumor-derived, having their origin in other organs and cell types. Hence, liquid biopsies provide a source of direct tumor cell-derived biomolecules and indirect nontumor-derived surrogate markers that circulate in body fluids or are taken up by circulating peripheral blood cells. The capacity of platelets to take up proteins and nucleic acids and alter their megakaryocyte-derived transcripts and proteins in response to external signals makes them one of the richest liquid biopsy biosources. Platelets are the second most abundant cell type in peripheral blood and are routinely isolated through well-established and fast methods in clinical diagnostics but their value as a source of cancer biomarkers is relatively recent. Platelets do not have a nucleus but have a functional spliceosome and protein translation machinery, to process RNA transcripts. Platelets emerge as important repositories of potential cancer biomarkers, including several types of RNAs (mRNA, miRNA, circRNA, lncRNA, and mitochondrial RNA) and proteins, and several preclinic...Continue Reading

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Citations

May 7, 2021·Journal of Clinical Laboratory Analysis·Xinxin GeKesheng Dai
Jul 3, 2021·International Journal of Molecular Sciences·Yeonsoo ChaeWanyeon Kim

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Software Mentioned

thromboSeq
DigiWest
digitalSWARM
PSO
Nanostring
DA
PLS

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