PMID: 16523191Mar 9, 2006Paper

Circulating procoagulant microparticles in obesity

Diabetes & Metabolism
B GoichotC Simon

Abstract

Obesity is a risk factor for cardiovascular diseases and venous thromboembolism. Circulating procoagulant microparticles (MP) have been described in various clinical situations associated with thrombosis and in diabetic patients. The aim of this preliminary study was to evaluate the presence of MP in obese patients without any other vascular risk factor in particular diabetes. Fifty-eight obese women <50 year-old without other cardiovascular risk factors were recruited from a single out-patient nutrition clinic. They were compared to 45 age-matched healthy normal weight controls. Main outcome was MP levels in patients and controls. Relationships between MP concentrations and parameters reflecting insulin resistance in patients were also studied. Obese patients were 33.3 +/- 1.2 years old and had a mean BMI of 42.4 +/- 0.9 kg/m2. There vas a greater proportion of smokers in the obese group (34.5 vs 15.6%). Mean MP levels were markedly higher in obese patients compared to controls (10.6 +/- 0.5 vs 3.2 +/- 0.3 nMPSeq, P < 0.001). There was no difference in MP concentrations between smokers and non smokers. In the obese group, there was a negative correlation between MP and BMI (r = -0.265, P < 0.05) but no relationship could be es...Continue Reading

References

Aug 28, 2002·Diabetes·Florence SabatierFrancoise Dignat-George
Jan 2, 2003·Journal of Endocrinological Investigation·G De Pergola, N Pannacciulli
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·I Juhan-VagueP E Morange
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·J-M Freyssinet
Aug 12, 2003·Cardiovascular Research·Marja J VanWijkR Nieuwland

❮ Previous
Next ❯

Citations

Aug 17, 2010·Journal of Thrombosis and Thrombolysis·Richard C Becker
Feb 26, 2011·Journal of Thrombosis and Thrombolysis·Richard C Becker
Jun 1, 2012·International Journal of Obstetric Anesthesia·E S MorganB J Hunt
Dec 28, 2010·European Heart Journal·Jan-Malte SinningNikos Werner
Aug 28, 2012·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Günter Müller
Dec 18, 2013·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Masoud RezvaniGintaras Antanavicius
Feb 6, 2013·Nutrition & Diabetes·M J AlkhatatbehL F Lincz
Feb 4, 2016·Internal and Emergency Medicine·Elena CampelloPaolo Simioni
Nov 26, 2011·Best Practice & Research. Clinical Obstetrics & Gynaecology·Gabriella Gray, Catherine Nelson-Piercy
Dec 1, 2015·Pharmacology & Therapeutics·Edward MilbankRamaroson Andriantsitohaina
Jun 19, 2010·Advanced Drug Delivery Reviews·Peter J Quesenberry, Jason M Aliotta
Oct 23, 2015·The Journal of Surgical Research·Zheng WangMelina R Kibbe
Dec 2, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L AyG Schernthaner
Dec 22, 2015·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Annick SteibFlorence Toti
Nov 18, 2015·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Jean Amiral, Jerard Seghatchian
May 17, 2013·Thrombosis and Haemostasis·E P FeenerW Fickweiler
Apr 4, 2009·American Journal of Reproductive Immunology : AJRI·Christianne A R LokJoris A M Van Der Post
Aug 11, 2010·Journal of Thrombosis and Haemostasis : JTH·E ShantsilaG Y H Lip
Mar 18, 2016·International Journal of Molecular Sciences·Linda A BanSusan V McLennan
Oct 21, 2011·American Journal of Reproductive Immunology : AJRI·Christine A R LokMarijke M Faas
Mar 6, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·G Al-MassaraniL Camoin-Jau
Nov 5, 2011·Journal of Cellular and Molecular Medicine·Morgane BaronAnne Tailleux
Jul 23, 2016·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Amihai RottenstreichYosef Kalish
Aug 1, 2016·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Jean Amiral, Jerard Seghatchian
Feb 24, 2017·Environmental Research·Matteo BonziniValentina Bollati
Jan 13, 2018·Frontiers in Cardiovascular Medicine·Lina BadimonTeresa Padró
Apr 22, 2009·Journal of Cellular and Molecular Medicine·F SabatierF Dignat-George
Oct 17, 2017·Frontiers in Endocrinology·Júnia Raquel Dutra FerreiraMarilda de Souza Gonçalves
Sep 7, 2018·Frontiers in Cardiovascular Medicine·Annemiek Dickhout, Rory R Koenen
Aug 4, 2020·The Clinical Respiratory Journal·Aydanur EkiciHabibe Aslan
Jan 11, 2020·Frontiers in Pharmacology·Silvia OggeroLucy Victoria Norling
Feb 1, 2019·Journal of Thrombosis and Thrombolysis·Armando TripodiFlora Peyvandi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.