Circulating Proenkephalin, Acute Kidney Injury, and Its Improvement in Patients with Severe Sepsis or Shock

Clinical Chemistry
Pietro CaironiALBIOS Study Investigators

Abstract

Acute kidney injury (AKI) occurs in many critically ill patients and is associated with high mortality. We examined whether proenkephalin could predict incident AKI and its improvement in septic patients. Plasma proenkephalin A 119-159 (penKid) was assayed in 956 patients with sepsis or septic shock enrolled in the multicenter Albumin Italian Outcome Sepsis (ALBIOS) trial to test its association with incident AKI, improvement of renal function, need for renal replacement therapy (RRT), and mortality. Median [Q1-Q3] plasma penKid concentration on day 1 [84 (20-159) pmol/L[ was correlated with serum creatinine concentration (r = 0.74); it was higher in patients with chronic renal failure and rose progressively with the renal Sequential Organ Failure Assessment subscore. It predicted incident AKI within 48 h (adjusted odds ratio, 3.3; 95% CI, 2.1-5.1; P < 0.0001) or 1 week [adjusted hazard ratio, 2.1 (1.7-2.8); P < 0.0001] and future RRT during the intensive care unit stay [odds ratio, 4.0 (3.0-5.4)]. PenKid was also associated with improvements in renal function in patients with baseline serum creatinine >2 mg/dL, both within the next 48 h [adjusted odds ratio, 0.31 (0.18-0.54), P < 0.0001] and 1 week [0.23 (0.12-0.45)]. The time...Continue Reading

References

Sep 24, 2013·Critical Care : the Official Journal of the Critical Care Forum·Lakhmir S ChawlaMichael G Seneff
Mar 19, 2014·The New England Journal of Medicine·Pietro CaironiUNKNOWN ALBIOS Study Investigators
Apr 20, 2014·Clinical Journal of the American Society of Nephrology : CJASN·John R ProwleChristopher J Kirwan
May 23, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Bulent ErginCan Ince
Dec 17, 2014·Clinical Nephrology·Kevin S ShahAlan S Maisel
Jul 15, 2015·Intensive Care Medicine·M SchetzG Van den Berghe
Jan 24, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Martin Hermann BernardiAndrea Lassnigg
Jan 28, 2016·The Journal of Trauma and Acute Care Surgery·Kyle J GunnersonUNKNOWN Sapphire Topaz investigators
Feb 27, 2016·The American Journal of Cardiology·Boris ArbitAlan S Maisel
Jun 28, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Michael HeungUNKNOWN Sapphire and Topaz Investigators
Jul 13, 2016·Journal of the American Society of Nephrology : JASN·Christina-Alexandra SchulzMarju Orho-Melander
Sep 28, 2016·Critical Care : the Official Journal of the Critical Care Forum·Marlies Ostermann, Michael Joannidis
Jan 7, 2017·Journal of the American College of Cardiology·Leong L NgUNKNOWN GREAT Network
Jan 12, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Kianoush KashaniClaudio Ronco
Feb 1, 2017·Intensive Care Medicine·Peter PickkersMiet Schetz
Apr 2, 2017·Intensive Care Medicine·Rinaldo BellomoAntoine Schneider
May 4, 2017·Intensive Care Medicine·L G ForniM Joannidis
Jun 1, 2017·Lancet·Jill VanmassenhoveWim Van Biesen
Jun 29, 2017·International Journal of Molecular Sciences·Christian NusshagThorsten Brenner
Aug 11, 2017·Transplantation Direct·Lyanne M KienekerStephan J L Bakker
Nov 1, 2017·The Journal of Applied Laboratory Medicine·Remi BeundersPeter Pickkers

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Citations

Oct 18, 2018·Clinical Chemistry and Laboratory Medicine : CCLM·Alan H B Wu, Inder Anand
Jun 17, 2020·Annals of Laboratory Medicine·Hanah KimSalvatore Di Somma
Aug 25, 2020·Annals of Laboratory Medicine·Christian AlbertAnja Haase-Fielitz
Jun 10, 2020·American Journal of Respiratory and Critical Care Medicine·François DépretMatthieu Legrand
Sep 1, 2021·Clinical Journal of the American Society of Nephrology : CJASN·Anitha VijayanUNKNOWN AKI!NOW Steering Committee
Jan 29, 2020·Burns : Journal of the International Society for Burn Injuries·François DépretUNKNOWN PRONOBURN group
Sep 18, 2021·Current Opinion in Critical Care·Khaschayar Saadat-Gilani, Alexander Zarbock

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