Circulating progenitor cell count for cardiovascular risk stratification: a pooled analysis.

PloS One
Gian Paolo FadiniNikos Werner

Abstract

Circulating progenitor cells (CPC) contribute to the homeostasis of the vessel wall, and a reduced CPC count predicts cardiovascular morbidity and mortality. We tested the hypothesis that CPC count improves cardiovascular risk stratification and that this is modulated by low-grade inflammation. We pooled data from 4 longitudinal studies, including a total of 1,057 patients having CPC determined and major adverse cardiovascular events (MACE) collected. We recorded cardiovascular risk factors and high-sensitive C-reactive protein (hsCRP) level. Risk estimates were derived from Cox proportional hazard analyses. CPC count and/or hsCRP level were added to a reference model including age, sex, cardiovascular risk factors, prevalent CVD, chronic renal failure (CRF) and medications. The sample was composed of high-risk individuals, as 76.3% had prevalent CVD and 31.6% had CRF. There were 331 (31.3%) incident MACE during an average 1.7+/-1.1 year follow-up time. CPC count was independently associated with incident MACE even after correction for hsCRP. According to C-statistics, models including CPC yielded a non-significant improvement in accuracy of MACE prediction. However, the integrated discrimination improvement index (IDI) showed ...Continue Reading

References

May 1, 1976·American Journal of Epidemiology·K J Rothman
Dec 23, 1971·The New England Journal of Medicine·P A McKeeW B Kannel
Aug 8, 2001·The Journal of Clinical Investigation·S DimmelerA M Zeiher
Dec 20, 2002·Nature·Peter Libby
Aug 21, 2003·JAMA : the Journal of the American Medical Association·Umesh N KhotEric J Topol
Aug 21, 2003·JAMA : the Journal of the American Medical Association·Daniel G Hackam, Sonia S Anand
Oct 2, 2003·Vascular Medicine·Peter Leong-Sit, Sonia S Anand
Feb 28, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Volker AdamsRainer Hambrecht
Apr 13, 2004·International Journal of Epidemiology·George Davey Smith, Shah Ebrahim
Jun 9, 2004·Circulation·Akihiko TaguchiHiroaki Naritomi
Jun 12, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Takahisa KondoToyoaki Murohara
Aug 24, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Stefanie Dimmeler, Andreas M Zeiher
Sep 9, 2005·The New England Journal of Medicine·Nikos WernerGeorg Nickenig
Sep 9, 2005·The New England Journal of Medicine·Anthony Rosenzweig
Oct 13, 2005·Statistics in Medicine·Lloyd E Chambless, Guoqing Diao
Apr 22, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Giuseppe CroceGiovambattista Desideri
Jun 27, 2006·Experimental Hematology·Michiharu SakuraiEiichi Momotani
Aug 17, 2006·European Heart Journal·Gian Paolo FadiniAngelo Avogaro
Dec 22, 2006·The New England Journal of Medicine·Thomas J WangRamachandran S Vasan
May 12, 2007·Atherosclerosis·Gian Paolo FadiniAngelo Avogaro
Feb 6, 2008·Atherosclerosis·Gian Paolo FadiniAngelo Avogaro
May 16, 2008·The New England Journal of Medicine·Björn ZetheliusJohan Arnlöv
May 31, 2008·American Journal of Epidemiology·Guang Yong Zou
Jun 3, 2008·European Heart Journal·Jochen Müller-EhmsenMarkus Flesch
Jul 23, 2008·Perspectives in Vascular Surgery and Endovascular Therapy·Kimon Bekelis, Nicos Labropoulos
Oct 10, 2008·Kidney International·Shoichi MaruyamaSeiichi Matsuo
Nov 11, 2008·The New England Journal of Medicine·Paul M RidkerUNKNOWN JUPITER Study Group
Jul 2, 2009·JAMA : the Journal of the American Medical Association·Olle MelanderThomas J Wang
Jul 2, 2009·JAMA : the Journal of the American Medical Association·Svati H Shah, James A de Lemos

❮ Previous
Next ❯

Citations

Nov 13, 2010·PloS One·Caroline Schmidt-LuckeStefanie Dimmeler
Feb 22, 2012·Circulation Research·Gian Paolo FadiniStefanie Dimmeler
Nov 1, 2012·Diabetes Care·Gian Paolo FadiniAngelo Avogaro
May 2, 2012·Experimental Diabetes Research·Gian Paolo Fadini, Angelo Avogaro
Jan 5, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Carolina N FrançaFrancisco A H Fonseca
Aug 9, 2011·Experimental Diabetes Research·Stella BernardiPaola Secchiero
Mar 7, 2014·Journal of Cardiac Failure·Alexander E Berezin, Alexander A Kremzer
Dec 21, 2010·Archivos de la Sociedad Española de Oftalmología·A Villalvilla, R Fernández-Durango
Oct 23, 2012·Free Radical Biology & Medicine·Norifumi Urao, Masuko Ushio-Fukai
Mar 28, 2012·Experimental Gerontology·Giuseppe MandraffinoAntonino Saitta
Jan 13, 2012·Thrombosis Research·Eugenia Rosa NuzzoloLuciana Teofili
Jun 15, 2011·Vascular Pharmacology·Gian Paolo Fadini, Angelo Avogaro
Jan 5, 2014·Pacing and Clinical Electrophysiology : PACE·Natália AntónioGuilherme Mariano Pego
May 20, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Giuseppe MandraffinoAntonino Saitta
Oct 5, 2017·Journal of the American Heart Association·Matthew L TopelArshed A Quyyumi
Jul 21, 2016·Circulation Research·Ibhar Al MheidArshed A Quyyumi
Jan 17, 2015·Circulation Research·Gian Paolo Fadini
Jan 21, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Gaia SpinettiPaolo Madeddu
Jan 1, 2020·European Heart Journal·Gian Paolo FadiniArshed Ali Quyyumi
Feb 9, 2018·Diabetes, Obesity & Metabolism·Maria P A BaldassarreTina Vilsbøll

❮ Previous
Next ❯

Methods Mentioned

BETA
amputation

Software Mentioned

SPSS

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.