Circulating Prostaglandin Biosynthesis in Colorectal Cancer and Potential Clinical Significance

EBioMedicine
Haitao LiZigang Dong

Abstract

Colorectal cancer (CRC) represents the third leading cause of cancer-related death in the United States. Lack of reliable biomarkers remains a critical issue for early detection of CRC. In this study, we investigated the potential predictive values of circulating prostaglandin (PG) biosynthesis in CRC risk. Profiles of circulating PG biosynthesis and platelet counts were determined in healthy subjects (n = 16), familial adenomatous polyposis (FAP) patients who were classified as regular aspirin users (n = 14) or nonusers (n = 24), and CRC patients with (n = 18) or without FAP history (n = 20). Immunohistochemistry staining was performed on biopsy samples. Analysis of circulating PG biosynthesis unexpectedly revealed that CRC progression is accompanied by a pronounced elevation of circulating thromboxane A2 (TXA2) levels. When a circulating TXA2level of 1000 pg/mL was selected as a practical cutoff point, 95% of CRC patients were successfully identified. Further study suggested that the TXA2pathway is constitutively activated during colorectal tumorigenesis and required for anchorage-independent growth of colon cancer cells. This study established the importance of the TXA2pathway in CRC pathophysiology, and laid the groundwork ...Continue Reading

References

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Citations

Jul 3, 2015·EBioMedicine·Alexander GreenhoughAnn C Williams
Jul 23, 2015·Prostaglandins & Other Lipid Mediators·Karsten Schrör, Bernhard H Rauch
Sep 7, 2017·International Journal of Cancer. Journal International Du Cancer·Carina HasenoehrlRudolf Schicho
Jun 2, 2018·Medicinal Research Reviews·Hui HuaYangfu Jiang
Oct 9, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ewa ŻyłaJoanna Gromadzka-Ostrowska
Jun 3, 2018·Cancer Metastasis Reviews·Yuxin WangGuodong Zhang
Apr 3, 2017·NPJ Precision Oncology·Haitao LiZigang Dong
Jun 25, 2016·Cancer Prevention Research·Yang-Yi FanRobert S Chapkin
Dec 10, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Qiaowei FanHulun Li
Apr 4, 2021·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Christoph SchmöckerKarsten H Weylandt
May 1, 2021·Frontiers in Cardiovascular Medicine·Mario Álvarez-MaestroMercedes Ferrer
May 18, 2018·Journal of Agricultural and Food Chemistry·Wenzhe WangWei Chen

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Methods Mentioned

BETA
Assay
biopsy

Software Mentioned

Image Pro - Plus
Image
Pro Plus
Prism

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