Circulating RNAs as Potential Biomarkers in Amyotrophic Lateral Sclerosis

International Journal of Molecular Sciences
Metka Ravnik-Glavač, Damjan Glavač

Abstract

Amyotrophic lateral sclerosis (ALS) is a complex multi-system neurodegenerative disorder with currently limited diagnostic and no therapeutic options. Despite the intense efforts no clinically applicable biomarkers for ALS are yet established. Most current research is thus focused, in particular, in identifying potential non-invasive circulating biomarkers for more rapid and accurate diagnosis and monitoring of the disease. In this review, we have focused on messenger RNA (mRNA), non-coding RNAs (lncRNAs), micro RNAs (miRNAs) and circular RNA (circRNAs) as potential biomarkers for ALS in peripheral blood serum, plasma and cells. The most promising miRNAs include miR-206, miR-133b, miR-27a, mi-338-3p, miR-183, miR-451, let-7 and miR-125b. To test clinical potential of this miRNA panel, a useful approach may be to perform such analysis on larger multi-center scale using similar experimental design. However, other types of RNAs (lncRNAs, circRNAs and mRNAs) that, together with miRNAs, represent RNA networks, have not been yet extensively studied in blood samples of patients with ALS. Additional research has to be done in order to find robust circulating biomarkers and therapeutic targets that will distinguish key RNA interactions ...Continue Reading

References

Apr 25, 2000·Molecular and Cellular Biology·L YangD D Hickstein
Jun 6, 2000·Brain Research. Molecular Brain Research·M RaghunathC Damodar Reddy
Feb 14, 2003·Journal of Neuroscience Research·Laura ConfortiCaterina Bendotti
Apr 3, 2003·Brain Research. Molecular Brain Research·Mineko TomomuraRyoji Yano
Mar 30, 2004·Annals of Neurology·Nicholas J MaragakisJeffrey D Rothstein
Aug 6, 2005·The Journal of Comparative Neurology·Anneliese M SchaeferJeff W Lichtman
Oct 18, 2005·Nature Genetics·Marc BitounPascale Guicheney
Jan 2, 2007·Trends in Cell Biology·Ramesh S PillaiWitold Filipowicz
Mar 1, 2008·Science·Jemeen SreedharanChristopher E Shaw
Feb 5, 2009·Annals of Neurology·Jeffrey D Rothstein
Jul 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Eunsung JunnM Maral Mouradian
Sep 24, 2009·Nature Reviews. Molecular Cell Biology·Nobutaka HirokawaShinsuke Niwa
Mar 13, 2010·Neuron·Xianghui ZhaoQ Richard Lu
Jul 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Shuo-Chien LingDon W Cleveland
Aug 12, 2010·Human Molecular Genetics·Daryl A BoscoLawrence J Hayward
Sep 18, 2010·Clinical Chemistry·Jessica A WeberKai Wang
Jul 2, 2011·Journal of Molecular Neuroscience : MN·Nicole SchonrockJürgen Götz
Aug 2, 2011·Cell·Leonardo SalmenaPier Paolo Pandolfi
Aug 5, 2011·Current Opinion in Neurobiology·Sandrine Da Cruz, Don W Cleveland
Aug 13, 2011·The Journal of Biological Chemistry·Gwang Hyeon EomSang-Beom Seo
Sep 15, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies· Markus Weber
Aug 7, 2012·The Journal of Clinical Investigation·Oleg ButovskyHoward L Weiner
Aug 21, 2012·Gene·Bruna De FeliceRoberto Cotrufo
Sep 6, 2012·Stroke; a Journal of Cerebral Circulation·Ashutosh DharapRaghu Vemuganti
Nov 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Maged M HarrazValina L Dawson
Nov 21, 2012·Molecular Neurodegeneration·Benjamin Wolozin
Jan 10, 2013·PloS One·Claudia Figueroa-RomeroEva L Feldman
Mar 1, 2013·Nature·Thomas B HansenJørgen Kjems
Mar 1, 2013·Nature·Sebastian MemczakNikolaus Rajewsky
May 25, 2013·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Martin R TurnerKenneth H Fischbeck
Jun 12, 2013·Trends in Neurosciences·Marc CrutsChristine Van Broeckhoven

❮ Previous
Next ❯

Citations

Dec 20, 2020·International Journal of Molecular Sciences·Leticia Moreno-GarcíaRosario Osta
Jan 26, 2021·Therapeutic Advances in Neurological Disorders·Tai-Heng Chen
Nov 12, 2020·Antioxidants·Ana Gámez-ValeroEulàlia Martí
Jun 8, 2021·Cancer Biomarkers : Section a of Disease Markers·Yong GuoJianjian Zheng
Jun 18, 2021·Journal of Cell Science·Eleonora GiagnorioStefania Marcuzzo
Aug 28, 2021·Biomolecules·Andrea BarpRiccardo Zuccarino

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPase
PCR

Software Mentioned

Google Scholar

Related Concepts

Related Feeds

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.