Circulating sCD27 and sCD30 in pre-diagnostic samples collected fifteen years apart and future non-Hodgkin lymphoma risk

International Journal of Cancer. Journal International Du Cancer
Mark P PurdueNathaniel Rothman

Abstract

Elevated serum sCD27 and sCD30 from a single banked sample have been associated with future non-Hodgkin lymphoma risk (NHL); however, the etiologic relevance of this finding is unclear. To address this question, we conducted a case-control study (235 cases, 235 controls) nested within the CLUE-I and CLUE-II cohorts, which enrolled participants in 1974 and 1989 respectively in Washington County, Maryland. Our study features a subset of 102 cases and 102 controls with two banked pre-diagnostic samples each, collected 15 years apart. In analyses involving an individual sample per subject, both sCD27 and sCD30 were associated with NHL diagnosed up to 20 years later. In analyses involving repeated samples, cases were significantly more likely than controls to have higher analyte levels in the CLUE-II vs. CLUE-I sample for sCD27 (p = 0.006) but not sCD30 (p = 0.16). In joint analyses of dichotomized analyte levels in both samples, the strongest NHL association observed for sCD27 was for having below-median levels in CLUE-I and above-median levels in CLUE-II [odds ratio (OR) 3.6, 95% confidence interval (CI) 1.4-9.2 vs. below-median levels in both). In joint analyses for sCD30, the strongest NHL association was observed for having abo...Continue Reading

References

Sep 17, 2003·Nature Reviews. Immunology·Michael Croft
Oct 5, 2010·Journal of Proteome Research·Elena Vendrame, Otoniel Martínez-Maza
Jul 26, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Roel VermeulenPaolo Vineis
Dec 7, 2011·Cancer Control : Journal of the Moffitt Cancer Center·Yvonne M Mowery, Mark C Lanasa
Aug 1, 2012·Cancer Research·Anneclaire J De RoosOtoniel Martínez-Maza
Jun 23, 2015·International Journal of Cancer. Journal International Du Cancer·Bryan A BassigNathaniel Rothman
Dec 20, 2015·International Journal of Cancer. Journal International Du Cancer·Fatemeh Saberi HosnijehRoel Vermeulen

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Sep 17, 2019·International Journal of Cancer. Journal International Du Cancer·Mark P PurdueNathaniel Rothman

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