Circulating sclerostin is elevated in short-term and reduced in long-term SCI.

Bone
R A BattaglinoL R Morse

Abstract

Spinal cord injury (SCI) causes profound bone loss due to muscle paralysis resulting in the inability to walk. Sclerostin, a Wnt signaling pathway antagonist produced by osteocytes, is a potent inhibitor of bone formation. Short-term studies in rodent models have demonstrated increased sclerostin in response to mechanical unloading that is reversed with reloading. Although sclerostin inhibition has been proposed as a potential therapy for bone loss, it is not known if sclerostin levels vary with duration of SCI in humans. We analyzed circulating sclerostin in 155 men with varying degrees of SCI who were 1 year or more post-injury. We report that sclerostin levels are greatest in subjects with short-term SCI (≤5 years post-injury) and decrease significantly over the first 5 years post-injury. There was no association between sclerostin and injury duration in subjects with long-term SCI (>5 years post-injury). In subjects with long-term SCI, sclerostin levels were positively associated with lower extremity bone density and bone mineral content. These data suggest that sclerostin levels are initially increased after SCI in response to mechanical unloading. This response is time-limited and as bone loss progresses, circulating scle...Continue Reading

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Citations

Sep 18, 2012·Current Osteoporosis Reports·Ricardo A BattaglinoLeslie R Morse
Mar 1, 2014·BoneKEy Reports·Bart L Clarke, Matthew T Drake
Oct 22, 2014·Current Opinion in Endocrinology, Diabetes, and Obesity·Mahalakshmi HonasogeSudhaker D Rao
May 15, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Weiping QinChristopher C Cardozo
Mar 19, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sara ThorsonJane A Cauley
Sep 6, 2012·Journal of Cellular and Molecular Medicine·Jun YanLei-Sheng Jiang
Nov 2, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Luke A BeggsJoshua F Yarrow
Jun 22, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ashley L DohertyLeslie R Morse
Dec 23, 2015·Topics in Spinal Cord Injury Rehabilitation·Karen L Troy, Leslie R Morse
Dec 9, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Laia GifrePilar Peris
Jul 15, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L R MorseE Garshick
Jul 21, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·W QinW A Bauman
Oct 6, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Faming TianDaniel D Bikle
Sep 5, 2013·The Journal of Clinical Endocrinology and Metabolism·Sonsoles BotellaNerea Varo
Dec 7, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C M CirnigliaroW A Bauman
Oct 12, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·W Brent EdwardsThomas J Schnitzer

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