Circulating senescent angiogenic T cells are linked with endothelial dysfunction and systemic inflammation in hypertension.

Journal of Hypertension
Gaoxing ZhangJiang He

Abstract

Angiogenic T cells (Tang cells), a recently discovered T-cell subset, have been reported involved in the repair of endothelial injury. The purpose of this study was to explore the correlation of immunologic senescence and pro-inflammatory capacity of Tang cells with endothelial dysfunction in hypertensive patients. Immunological characteristics of Tang cells (CD3+CD31+CXCR4+) from hypertensive patients with or without endothelial dysfunction were elucidated by surface immunophenotyping and intracellular cytokine staining. Endothelial function was measured by flow-mediated dilation (FMD). The frequency of CD28null subset in CD4+ Tang cells was notably elevated in hypertensive patients with endothelial dysfunction, which was negatively associated with FMD. The high frequency of CD28nullCD4+ Tang cells was an independent risk factor of endothelial dysfunction with good diagnostic performance in ROC curve analysis. Immunophenotyping revealed that this specific subset of Tang cells exhibited senescent profile and has low hTERT expression. CD28nullCD4+ Tang cells produced high levels of inflammatory cytokines, IL-6, IFN-γ and TNF-α, and significantly correlated with the systemic inflammation in hypertensive patients with endothelial ...Continue Reading

References

Jan 15, 2002·Journal of the American College of Cardiology·Mary C CorrettiUNKNOWN International Brachial Artery Reactivity Task Force
Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marielle ThewissenPiet Stinissen
Jun 23, 2009·Trends in Immunology·Nan-Ping WengJorg Goronzy
Oct 8, 2011·Stroke; a Journal of Cerebral Circulation·Rob P W RouhlJan Willem Cohen Tervaert
Jul 10, 2012·Circulation Research·Enrico AmmiratiGiuseppe Danilo Norata
Nov 17, 2012·American Journal of Respiratory and Critical Care Medicine·Slava BergerLena Lavie
Jan 9, 2014·Annals of the Rheumatic Diseases·Javier Rodríguez-CarrioAna Suárez
Aug 2, 2015·Journal of Leukocyte Biology·Patricia LópezAna Suarez
Dec 27, 2015·Acta Physiologica·P M VanhoutteE H C Tang
Jan 28, 2016·Aging and Disease·Xavier Castellon, Vera Bogdanova
May 29, 2016·Ageing Research Reviews·Ia PantsulaiaJolanta Niewiarowska
Nov 5, 2016·Journal of Hematology & Oncology·Claudia Zelle-RieserKarin Jöhrer
Aug 9, 2017·Hypertension·Tomasz J Guzik, Rhian M Touyz
Dec 16, 2017·Nature Immunology·Janko Nikolich-Žugich
Apr 18, 2018·Journal of Hypertension·Tatsuya MaruhashiYukihito Higashi
Jun 1, 2018·Oxidative Medicine and Cellular Longevity·Antonietta Gerarda GravinaAlessandro Federico
Aug 31, 2018·European Heart Journal·Bryan WilliamsUNKNOWN ESC Scientific Document Group
Jun 13, 2019·Nature Reviews. Immunology·Jörg J Goronzy, Cornelia M Weyand
Jun 13, 2020·Journal of the American College of Cardiology·Chi WangHao Xue
Jul 11, 2020·Journal of Hypertension·Luca ZanoliUNKNOWN Association for Research into Arterial Structure, Physiology (ARTERY) Society, the European Society of Hypertension (ESH) Wo

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

SPSS
Graphpad Prism
GraphPad
FlowJo

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.