Circulating SIRT1 Increases After Intragastric Balloon Fat Loss in Obese Patients

Obesity Surgery
Stefania MarianiLucio Gnessi

Abstract

Sirtuins (SIRTs), ubiquitous deacetylases, are main regulators of energy homeostasis and metabolism. SIRT1 has a positive impact on obesity, diabetes mellitus, liver steatosis, and other metabolic disorders. Lean subjects have higher expression of SIRT1 in the adipose tissue compared to obese. However, it is not known whether weight loss associates with changes in blood SIRT1. We evaluated the effect of weight loss on circulating SIRT1, metabolic parameters, and body composition. Thirty-two obese subjects were studied before and 6 months after BioEnterics® Intragastric Balloon (BIB®) [22 patients, BMI 41.82 ± 6.28 kg/m(2)] or hypocaloric diet [10 patients, BMI 38.95 ± 6.90 kg/m(2)]. Plasma SIRT1, body composition, measures of metabolic syndrome (waist circumference, fasting plasma glucose, blood pressure, HDL cholesterol, triglycerides), and inflammation markers (ESR, CRP, fibrinogen) were recorded. SIRT1 levels showed a significant increase, together with a significant reduction of BMI, excess body weight, and total fat mass either after BIB or diet intervention. The percent excess body weight loss was 33.73 ± 19.06 and 22.08 ± 11.62 % after BIB and diet, respectively, a trend toward a metabolic and inflammatory amelioration w...Continue Reading

References

Jun 4, 2004·Nature·Frédéric PicardLeonard Guarente
Sep 29, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A GencoN Basso
Jun 19, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S B PedersenB Richelsen
Jul 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Paul T PflugerMatthias H Tschöp
Oct 27, 2010·Nature Communications·Daniel HerranzManuel Serrano
Nov 26, 2010·Nature Reviews. Cancer·Daniel Herranz, Manuel Serrano
Nov 24, 2011·Diabetes·Kae Won Cho, Carey N Lumeng
Nov 24, 2011·Diabetes·Matthew P GillumGerald I Shulman
Jun 26, 2012·International Journal of Cardiology·Stefania MarianiLucio Gnessi
Jun 28, 2013·Adipocyte·Maya E KotasMatthew P Gillum
Jun 12, 2014·American Journal of Physiology. Endocrinology and Metabolism·Timothy D CumminsBradford G Hill
Aug 12, 2014·Molecular and Cellular Endocrinology·Mar QuiñonesRuben Nogueiras

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Citations

Oct 26, 2016·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·S MarianiL Gnessi
Jan 25, 2017·The American Journal of Gastroenterology·Violeta B PopovChristopher C Thompson
May 16, 2018·The Journal of Veterinary Medical Science·Kuniko YoshimuraYasuyuki Momoi
Apr 25, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Paula Rodriguez-MiguelezRyan A Harris
Jul 16, 2020·Annals of the Rheumatic Diseases·George BatshonMona Dvir-Ginzberg
Dec 6, 2016·Journal of Experimental & Clinical Cancer Research : CR·Zhen MeiYongguang Tao
May 4, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Fateh BazerbachiBarham K Abu Dayyeh

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